{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:41:39Z","timestamp":1791452499086,"version":"4.3.3"},"reference-count":57,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH-funded Tennessee Center for AIDS Research","doi-asserted-by":"publisher","award":["P30 AI110527"],"award-info":[{"award-number":["P30 AI110527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH-funded Tennessee Center for AIDS Research","doi-asserted-by":"publisher","award":["UL1 TR002243"],"award-info":[{"award-number":["UL1 TR002243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["P30 AI110527"],"award-info":[{"award-number":["P30 AI110527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002243"],"award-info":[{"award-number":["UL1 TR002243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Tennessee is in the southern region of the United States and has not yet fully benefitted from HIV pre-exposure prophylaxis (PrEP). Relatively little research has focused on pivotal roles of PrEP navigators. This study examined PrEP navigator perceptions of implementing long-acting injectable (LAI) PrEP in Tennessee. Semi-structured interviews with state-funded navigators were audio-recorded, transcribed, and systematically coded using a hierarchical system. Coded transcripts were aggregated, sorted, and analyzed using an iterative inductive\/deductive qualitative approach. Using the Consolidated Framework for Implementation Research (CFIR), institutional, individual, and modifying factors to initiating and transitioning to LAI PrEP were identified. Most navigators initially had limited training and experience with LAI PrEP. Navigators reported systemic barriers associated with accessibility to LAI PrEP such as health insurance, pharmaceutical policies, and cost policies. While navigators noted the continued support of the state health department, strategies for circumventing individual and structural barriers are needed for universally implementing injectable PrEP.<\/jats:p>","DOI":"10.3390\/ijerph22050662","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T03:43:37Z","timestamp":1745379817000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PrEP Navigator Perceptions of the Implementation of Injectable PrEP on HIV Prevention in Tennessee"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-4357","authenticated-orcid":false,"given":"Cristian J.","family":"Chandler","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-9644","authenticated-orcid":false,"given":"David G.","family":"Schlundt","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Dagostino","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-3408","authenticated-orcid":false,"given":"Kemberlee R.","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7453-696X","authenticated-orcid":false,"given":"Ashley J.","family":"Sellers","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-8267","authenticated-orcid":false,"given":"Latrice C.","family":"Pichon","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Memphis, Memphis, TN 38152, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah R.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Public Health Practice, Meharry Medical College, Nashville, TN 37208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2019). Issue Brief: HIV in the Southern United States."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12954-018-0263-5","article-title":"Perspectives on HIV pre-exposure prophylaxis (PrEP) utilization and related intervention needs among people who inject drugs","volume":"15","author":"Biello","year":"2018","journal-title":"Harm Reduct. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s40615-023-01878-x","article-title":"HIV and Hepatitis C Among People Who Inject Drugs in Memphis, Tennessee: An Intersectional Risk Environment Analysis of the Social Determinants of Health","volume":"12","author":"Flath","year":"2023","journal-title":"J. Racial Ethn. Health Disparities"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.15585\/mmwr.mm7042a1","article-title":"HIV infection and HIV-associated behaviors among persons who inject drugs\u201423 metropolitan statistical areas, United States, 2018","volume":"70","author":"Handanagic","year":"2021","journal-title":"MMWR. Morb. Mortal. Wkly. Rep."},{"key":"ref_5","unstructured":"Tennessee Department of Health (2021). Tennessee HIV Epidemiological Profile, 2019."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Pichon, L.C., Teti, M., McGoy, S., Murry, V.M., and Juarez, P.D. (2022). Engaging Black men who have sex with men (MSM) in the South in identifying strategies to increase PrEP uptake. BMC Health Serv. Res., 22.","DOI":"10.1186\/s12913-022-08914-2"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1007\/s10461-018-2067-8","article-title":"Facilitators and barriers to pre-exposure prophylaxis (PrEP) use among black individuals in the United States: Results from the National Survey on HIV in the Black Community (NSHBC)","volume":"22","author":"Ojikutu","year":"2018","journal-title":"AIDS Behav."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/QAI.0000000000002112","article-title":"A gap between willingness and uptake: Findings from mixed methods research on HIV prevention among black and Latina transgender women","volume":"82","author":"Poteat","year":"2019","journal-title":"J. Acquir. Immune Defic. Syndr. (1999)"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Taggart, T., Liang, Y., Pina, P., and Albritton, T. (2020). Awareness of and willingness to use PrEP among Black and Latinx adolescents residing in higher prevalence areas in the United States. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0234821"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.amepre.2021.05.027","article-title":"Toward greater pre-exposure prophylaxis equity: Increasing provision and uptake for Black and Hispanic\/Latino individuals in the US","volume":"61","author":"Bonacci","year":"2021","journal-title":"Am. J. Prev. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1521\/aeap.2022.34.5.365","article-title":"Perceived barriers to and facilitators of long-acting injectable HIV PrEP use among Black, Hispanic\/Latino, and White gay, bisexual, and other men who have sex with men","volume":"34","author":"Tran","year":"2022","journal-title":"AIDS Educ. Prev."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Arnold, T., Brinkley-Rubinstein, L., Chan, P.A., Perez-Brumer, A., Bologna, E.S., Beauchamps, L., Johnson, K., Mena, L., and Nunn, A. (2017). Social, structural, behavioral and clinical factors influencing retention in Pre-Exposure Prophylaxis (PrEP) care in Mississippi. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172354"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1007\/s10461-019-02641-2","article-title":"The PrEP care continuum and black men who have sex with men: A scoping review of published data on awareness, uptake, adherence, and retention in PrEP care","volume":"23","author":"Ezennia","year":"2019","journal-title":"AIDS Behav."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11904-018-0385-0","article-title":"PrEP stigma: Implicit and explicit drivers of disparity","volume":"15","author":"Golub","year":"2018","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2105\/AJPH.2022.306793","article-title":"Associated costs are a barrier to HIV preexposure prophylaxis access in the United States","volume":"112","author":"Srikanth","year":"2022","journal-title":"Am. J. Public Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101989","DOI":"10.1016\/j.evalprogplan.2021.101989","article-title":"\u2018PrEP\u2019ing Memphis: A qualitative process evaluation of peer navigation support","volume":"90","author":"Pichon","year":"2022","journal-title":"Eval. Program Plan."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1002\/cncr.26262","article-title":"History and principles of patient navigation","volume":"117","author":"Freeman","year":"2011","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"dju115","DOI":"10.1093\/jnci\/dju115","article-title":"Impact of patient navigation on timely cancer care: The Patient Navigation Research Program","volume":"106","author":"Freund","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"87S","DOI":"10.1177\/0033354918803368","article-title":"Cross-site monitoring and evaluation of the Care and Prevention in the United States Demonstration Project, 2012-2016: Selected process and short-term outcomes","volume":"133","author":"Mulatu","year":"2018","journal-title":"Public Health Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/QAI.0000000000002274","article-title":"The HIV pre-exposure prophylaxis (PrEP) cascade at NYC sexual health clinics: Navigation is the key to uptake","volume":"83","author":"Pathela","year":"2020","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/QAI.0000000000002954","article-title":"A pilot study of a patient navigation intervention to improve HIV pre-exposure prophylaxis persistence among black\/African American men who have sex with men","volume":"90","author":"Goedel","year":"2022","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s10461-019-02657-8","article-title":"Temporal trends and sociodemographic correlates of PrEP uptake in Tennessee, 2017","volume":"23","author":"Brantley","year":"2019","journal-title":"AIDS Behav."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/15381501.2019.1655512","article-title":"Barriers to PrEP uptake: Perspectives of community health workers in the mid-South region of the United States","volume":"18","author":"Vaughn","year":"2019","journal-title":"J. HIV\/AIDS Soc. Serv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/COH.0000000000000597","article-title":"Long-acting injectable cabotegravir for the prevention of HIV infection","volume":"15","author":"Clement","year":"2020","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_25","unstructured":"U.S. Food and Drug Administration (2021). FDA Approves First Injectable Treatment for HIV Pre-Exposure Prevention."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s10461-017-1907-2","article-title":"Will gay and bisexual men taking oral pre-exposure prophylaxis (PrEP) switch to long-acting injectable PrEP should it become available?","volume":"22","author":"John","year":"2018","journal-title":"AIDS Behav."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1007\/s10461-020-02808-2","article-title":"Acceptability of long-acting injectable cabotegravir (CAB LA) in HIV-uninfected individuals: HPTN 077","volume":"24","author":"Tolley","year":"2020","journal-title":"AIDS Behav."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1007\/s12325-020-01295-0","article-title":"Barriers to the wider use of pre-exposure prophylaxis in the United States: A narrative review","volume":"37","author":"Mayer","year":"2020","journal-title":"Adv. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e207445","DOI":"10.1001\/jamanetworkopen.2020.7445","article-title":"Regional disparities in qualified health plans\u2019 prior authorization requirements for HIV pre-exposure prophylaxis in the United States","volume":"3","author":"McManus","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_30","first-page":"A4","article-title":"It\u2019s just not for me: Exploring low prep uptake among young black men who have sex with men in the southern united states","volume":"93","author":"Pingel","year":"2017","journal-title":"Sex. Transm. Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/jama.2022.0420","article-title":"Long-acting cabotegravir for HIV prevention: Issues of access, cost, and equity","volume":"327","author":"Sharfstein","year":"2022","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11904-019-00447-4","article-title":"Implementation strategies to increase PrEP uptake in the South","volume":"16","author":"Sullivan","year":"2019","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/intqhc\/mzm042","article-title":"Consolidated criteria for reporting qualitative research (COREQ): A 32-item checklist for interviews and focus groups","volume":"19","author":"Tong","year":"2007","journal-title":"Int. J. Qual. Health Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/160940690600500107","article-title":"Demonstrating rigor using thematic analysis: A hybrid approach of inductive and deductive coding and theme development","volume":"5","author":"Fereday","year":"2006","journal-title":"Int. J. Qual. Methods"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1108\/QRJ-D-18-00035","article-title":"Qualitative research: Deductive and inductive approaches to data analysis","volume":"18","author":"Azungah","year":"2018","journal-title":"Qual. Res. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1748-5908-4-50","article-title":"Fostering implementation of health services research findings into practice: A consolidated framework for advancing implementation science","volume":"4","author":"Damschroder","year":"2009","journal-title":"Implement. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13012-016-0437-z","article-title":"A systematic review of the use of the Consolidated Framework for Implementation Research","volume":"11","author":"Kirk","year":"2015","journal-title":"Implement. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1007\/s10461-021-03571-8","article-title":"Preferences for HIV preexposure prophylaxis products among black women in the US","volume":"26","author":"Irie","year":"2022","journal-title":"AIDS Behav."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11904-019-00450-9","article-title":"Current and future PrEP medications and modalities: On-demand, injectables, and topicals","volume":"16","author":"Beymer","year":"2019","journal-title":"Curr. Hiv\/Aids Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e660","DOI":"10.1016\/S2352-3018(21)00269-1","article-title":"Reassessing oral lead-in for injectable long-acting HIV therapy","volume":"8","author":"Llibre","year":"2021","journal-title":"Lancet HIV"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s40615-023-01729-9","article-title":"Barriers and Facilitators to Acceptability and Uptake of Pre-Exposure Prophylaxis (PrEP) Among Black Women in the United States: A Systematic Review","volume":"11","author":"Smit","year":"2023","journal-title":"J. Racial Ethn. Health Disparities"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chandler, R., Guillaume, D., Wells, J., and Hernandez, N. (2022). Let me prep you to PREP me: Amplifying the voices of black women and their providers to consider PrEP as an HIV prevention option. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031414"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/09540121.2022.2029816","article-title":"\u201cDo I want PrEP or do I want a roof?\u201d: Social determinants of health and HIV prevention in the southern United States","volume":"34","author":"Harrison","year":"2022","journal-title":"AIDS Care"},{"key":"ref_44","unstructured":"Centers for Disease Control and Prevention (2021). Preexposure Prophylaxis for the Prevention of HIV Infection in the United States\u20142021 Update a Clinical Practice Guideline."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1001\/jama.2023.14461","article-title":"Preexposure prophylaxis to prevent acquisition of HIV: US Preventive Services Task Force recommendation statement","volume":"330","author":"Barry","year":"2023","journal-title":"JAMA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1521\/aeap.2024.36.1.60","article-title":"Facilitators and Barriers to PrEP Acceptability and Initiation Among Opioid Treatment Program Patients and Staff","volume":"36","author":"Chan","year":"2024","journal-title":"AIDS Educ. Prev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s10461-019-02687-2","article-title":"From epidemiology to action: The case for addressing social determinants of health to end HIV in the Southern United States","volume":"23","author":"Jeffries","year":"2019","journal-title":"AIDS Behav."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Chory, A., and Bond, K. (2024). Access to PrEP and other sexual health services for cisgender women in the United States: A review of state policy and Medicaid expansion. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1360349"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1056\/NEJMp2216100","article-title":"Investing in national HIV PrEP preparedness","volume":"388","author":"Johnson","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/jme.2022.30","article-title":"Financing and Delivering Pre-Exposure Prophylaxis (PrEP) to End the HIV Epidemic","volume":"50","author":"Killelea","year":"2022","journal-title":"J. Law Med. Ethics"},{"key":"ref_51","unstructured":"Tennesee Department of Health (2022). HIV Drug Assistance Program Formulary."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s10461-020-03070-2","article-title":"Impact of Medicaid Expansion on PrEP Utilization in the US: 2012\u20132018","volume":"25","author":"Karletsos","year":"2021","journal-title":"AIDS Behav."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1521\/aeap.2024.36.5.324","article-title":"Longitudinal Impacts of Medicaid Expansion and Social Determinants of Health on PrEP Prevalence and PrEP-to-Need Ratio (PNR)","volume":"36","author":"Miller","year":"2024","journal-title":"AIDS Educ. Prev."},{"key":"ref_54","unstructured":"Farmer, B. (WPLN News, 2023). What We Know a Week After Tennessee Rejected Federal HIV Funding, WPLN News."},{"key":"ref_55","unstructured":"Tran, N.M., Rebeiro, P., and McKay, T. (2023). Tennessee Rejects Federal HIV Prevention Funds: A Looming Public Health And Financial Disaster. Health Aff. Forefr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e2326028","DOI":"10.1001\/jamanetworkopen.2023.26028","article-title":"Examination of HIV Preexposure Prophylaxis Need, Availability, and Potential Pharmacy Integration in the Southeastern US","volume":"6","author":"Harrington","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e054121","DOI":"10.1136\/bmjopen-2021-054121","article-title":"PrEP distribution in pharmacies: A systematic review","volume":"12","author":"Kennedy","year":"2022","journal-title":"BMJ Open"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/22\/5\/662\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:19:44Z","timestamp":1760030384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/22\/5\/662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["ijerph22050662"],"URL":"https:\/\/doi.org\/10.3390\/ijerph22050662","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]}}}