{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:02:02Z","timestamp":1791226922189,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"call for proposals Strategic Emergency Program for Preventing and Combating Outbreaks, Endemics, Epidemics and Pandemics of the Coordination for the Improvement of Higher Education Personnel (CAPES)","award":["0073\/2022"],"award-info":[{"award-number":["0073\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Anxiety, depression, and stress are prevalent psychosocial manifestations in Long COVID, and understanding their global impact can guide safe, effective, and evidence-based interventions. This study reviewed the literature to analyze the prevalence indicators and predictors of anxiety, depression, or stress experienced by adults and older adults with Long COVID. This systematic prevalence review was conducted using the databases MEDLINE via PubMed\u00ae, CINAHL-EBSCO, Web of Science, Scopus, EMBASE, LILACS, and BDENF. Observational studies that assessed anxiety, depression, or perceived stress in adults and older adults with Long COVID were included, with no restrictions on time or language. Two reviewers independently conducted the selection process. Full texts were analyzed for their eligibility potential. Methodological quality was assessed using the JBI Critical Appraisal Checklist for Studies. Ten observational studies with moderate methodological quality were included. Anxiety and depression were the most prevalent psychosocial symptoms in Long COVID, reported in mild, moderate, and severe cases of COVID-19 infection. Prevalence rates reached up to 47.8% for anxiety, 37.3% for depression, and 23% for stress. The combined analysis revealed a pooled prevalence of 15.3% (95% CI: 10.8% to 20.2%). Being female, having pre-existing mental disorders or associated clinical comorbidities, experiencing severe infection in the acute phase, and receiving intensive care were predictors of greater mental burden. The experience of anxiety, depression, and stress in prolonged COVID-19 was reported in countries with different income levels and was disproportionately experienced, especially by women and individuals with associated clinical conditions or psychopathological comorbidities.<\/jats:p>","DOI":"10.3390\/ijerph22060867","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:57:18Z","timestamp":1748923038000},"page":"867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of Anxiety, Depression, and Stress in Long COVID: Systematic Review of Prevalence"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-2143","authenticated-orcid":false,"given":"Daniel de Mac\u00eado","family":"Rocha","sequence":"first","affiliation":[{"name":"Department of Nursing, Federal University of Mato Grosso do Sul, Coxim 79400-000, Brazil"},{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-1666","authenticated-orcid":false,"given":"Andrey Oeiras","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-4484","authenticated-orcid":false,"given":"Mayra Gon\u00e7alves","family":"Menegueti","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-3640","authenticated-orcid":false,"given":"Renata Cristina de Campos Pereira","family":"Silveira","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-5439","authenticated-orcid":false,"given":"Laelson Rochelle Milan\u00eas","family":"Sousa","sequence":"additional","affiliation":[{"name":"Nursing Course, State University of Maranh\u00e3o, Coroat\u00e1 65665-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elucir","family":"Gir","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-4721","authenticated-orcid":false,"given":"Renata Karina","family":"Reis","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: Major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat. 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