{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:43:38Z","timestamp":1789753418086,"version":"4.0.1"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)\u2013Brazil","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)\u2013Brazil","award":["E-26\/201.436\/2021"],"award-info":[{"award-number":["E-26\/201.436\/2021"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","award":["E-26\/201.436\/2021"],"award-info":[{"award-number":["E-26\/201.436\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: COVID-19 led to social isolation, potentially reducing physical activity (PA), increasing sedentary time, and lowering quality of life (QoL). This study investigated the association between these factors in patients with Chagas disease (ChD) during the pandemic. Methods: This cross-sectional study included 187 patients with ChD. PA and sedentary time were assessed by the IPAQ-short and QoL by the WHOQOL-Bref. The relationship between PA levels and sedentary time with QoL were assessed using unadjusted and adjusted generalized linear models. Results: The highest tertile of total PA was positively associated with the psychological (Exp \u03b2 = 1.11; 95% CI: 1.02\u20131.22) and environmental (Exp \u03b2 = 1.12; 95% CI: 1.01\u20131.23) QoL domains. The intermediate (Exp \u03b2 = 1.12; 95% CI: 1.01\u20131.25) and highest (Exp \u03b2 = 1.14; 95% CI: 1.02\u20131.27) tertiles of moderate-to-vigorous PA were positively associated with the physical domain. Similarly, both the intermediate (Exp \u03b2 = 1.11; 95% CI: 1.01\u20131.22) and highest (Exp \u03b2 = 1.12; 95% CI: 1.01\u20131.21) tertiles of moderate-to-vigorous PA were positively associated with the psychological domain. The highest tertile of sedentary time was associated with a decrease in the physical domain (Exp \u03b2 = 0.88; 95% CI: 0.79\u20130.98). Conclusions: Higher levels of total and moderate-to-vigorous PA were associated with better QoL, while greater sedentary time was associated with poorer QoL.<\/jats:p>","DOI":"10.3390\/ijerph22071137","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T10:10:38Z","timestamp":1752833438000},"page":"1137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Physical Activity, Sedentary Time, and Quality of Life in Patients with Chagas Disease During COVID-19 Pandemic in Brazil: A Cross-Sectional Study"],"prefix":"10.3390","volume":"22","author":[{"given":"Isis Gabrielli Gomes","family":"Xavier","sequence":"first","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-6963","authenticated-orcid":false,"given":"Patr\u00edcia Mello","family":"Andrade","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo de Lima","family":"Vitor","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayn\u00e1 Cruz","family":"Barros","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whesley Tanor","family":"Silva","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Fernandes","family":"Portela","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3125-6610","authenticated-orcid":false,"given":"Marcelo Teixeira de","family":"Holanda","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Henrique Conde","family":"Sangenis","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto Marcelo Sperandio da","family":"Silva","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Mazzoli-Rocha","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda de Souza Nogueira Sardinha","family":"Mendes","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Rodrigues da","family":"Costa","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Carvalho","family":"Vieira","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Service, Aloysio de Castro State Institute of Cardiology, Rio de Janeiro 20261-005, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-4774","authenticated-orcid":false,"given":"Daniela Palheiro Mendes de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Maria","family":"Valete","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"},{"name":"Department of Otorhinolaryngology and Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-7222","authenticated-orcid":false,"given":"Alejandro Marcel","family":"Hasslocher-Moreno","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Silveira","family":"Costa","sequence":"additional","affiliation":[{"name":"Postgraduate course in Rehabilitation and Functional Performance, Physiotherapy Department, Federal University of Vales do Jequitinhonha and Mucuri (UFVJM), Diamantina 39100-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4972-1269","authenticated-orcid":false,"given":"Vitor Barreto","family":"Paravidino","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro 20550-013, RJ, Brazil"},{"name":"National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Rehder","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro 20550-013, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-4261","authenticated-orcid":false,"given":"Roberto 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