{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:35:36Z","timestamp":1791441336560,"version":"4.3.3"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Non-adherence to anti-tuberculosis treatment remains a major obstacle to increasing tuberculosis treatment success rates and enhancing healthcare expenditure. The aim of this study was to identify determinants contributing to non-adherence to anti-tuberculosis treatment in a public primary healthcare clinic in South Africa. Method: A cross-sectional study was carried out to collect data from 65 participants using face-to-face interviews with a structured questionnaire. Data were analyzed using SPSS. Results: Of the 65 participants interviewed, 41 (63.08%) were males and 24 (36.92%) were females. A total of 45 (69.23%) were adherents and 20 (30.77%) were non-adherents. Gender was the major predictor of non-adherence with more males committed to treatment than females with a significant association (X2 = 65.00 and p of &lt;0.001). Conclusions: The major contributing factors to non-adherence were long dis-tances to the clinics, a lack of family support, and unemployment. Comprehensive programs addressing these multifactorial factors are needed for successful treatment and eradication of tuberculosis.<\/jats:p>","DOI":"10.3390\/ijerph22081209","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:37:47Z","timestamp":1754030267000},"page":"1209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Determinants of Non-Adherence to Anti-Tuberculosis Treatment in a Public Primary Healthcare Clinic in South Africa: Improving the Quality of Long-Term Care"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5398-3253","authenticated-orcid":false,"given":"Lucky Norah","family":"Katende-Kyenda","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Pharmacology, Faculty of Medicine and Health Sciences, Walter Sisulu University, Sissons Street, Fortgale, Mthatha 5117, Eastern Cape, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, January 06). Tuberculosis, Key Facts. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/tuberculosis."},{"key":"ref_2","unstructured":"World Health Organization (2025, February 01). TB Overview. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/tuberculosis."},{"key":"ref_3","unstructured":"World Health Organization (2025, February 02). Global Tuberculosis Report, Tuberculosis. Available online: https:\/\/www.who.int\/health-topics\/tuberculosis#tab=tab_1."},{"key":"ref_4","unstructured":"World Health Organization (2025, February 05). Tuberculosis Resurges as Top Infectious Disease Killer. Available online: https:\/\/www.who.int\/news\/item\/29-10-2024-tuberculosis-resurges-as-top-infectious-disease-killer."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12981-024-00657-w","article-title":"Association of ART regimen and adherence to viral suppression: An observational study of a clinical population of people with HIV","volume":"21","author":"Manalel","year":"2024","journal-title":"AIDS Res. Ther."},{"key":"ref_6","unstructured":"World Health Organization (2025, March 05). Tuberculosis Mortality Has Nearly Halved Since 1990. Available online: https:\/\/www.who.int\/news\/item\/28-10-2015-tuberculosis-mortality-nearly-halved-since-1990."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"a6030","DOI":"10.4102\/safp.v67i1.6030","article-title":"Factors associated with successful treatment outcomes among tuberculosis patients in a district municipality of Vhembe, Limpopo","volume":"67","author":"Mkhavele","year":"2025","journal-title":"S. Afr. Fam. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"04004","DOI":"10.7189\/jogh.15.04004","article-title":"Health system and environmental factors affecting global progress towards achieving End TB targets between 2015 and 2020","volume":"15","author":"Wolde","year":"2025","journal-title":"J. Glob. Health"},{"key":"ref_9","unstructured":"World Health Organization (2025, June 10). The End TB Strategy. Available online: https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/the-end-tb-strategy."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Houben, R.M.G.J., and Dodd, P.J. (2016). The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling. PLoS Med., 13.","DOI":"10.1371\/journal.pmed.1002152"},{"key":"ref_11","unstructured":"United Nations (2024). Sustainable Development Goals. Ensure Healthy Lives and Promote Well-Being for All Ages, United Nations. Available online: https:\/\/www.un.org\/sustainabledevelopment\/health."},{"key":"ref_12","first-page":"101015","article-title":"Directly observed treatment for tuberculosis care and social support: Essential lifeline or outdated burden?","volume":"43","author":"Croda","year":"2025","journal-title":"Lancet Reg. Health-Am."},{"key":"ref_13","unstructured":"WHO (1999). What Are DOTS? A Guide to Understanding the WHO Recommended TB Control Strategy Known as DOTS, WHO. Available online: https:\/\/iris.who.int\/bitstream\/handle\/10665\/65979\/WHO_CDS_CPC_TB_99.270.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Tirore, L., Ersido, T., Handiso, T.B., and Areba, A.S. (2024). Non-adherence to anti-tuberculosis treatment and associated factors among TB patients in public health facilities of Hossana town, Southern Ethiopia, 2022. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1360351"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lolong, D.B., Aryastami, N.K., Kusrini, I., Tobing, K.L., Tarigan, I., Isfandari, S., Senewe, F.P., Endah, N., and Sitorus, N. (2023). Nonadherence to anti-tuberculosis treatment, reasons and associated factors among pulmonary tuberculosis patients in the communities in Indonesia. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0287628"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4236\/jtr.2020.82008","article-title":"Patient Characteristics Associated with Non-Adherence to Tuberculosis Treatment: A Systematic Review","volume":"8","author":"Ali","year":"2020","journal-title":"J. Tuberc. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s41467-024-45491-w","article-title":"Spotlight on the tuberculosis epidemic in South Africa","volume":"15","author":"Mizrah","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1372","DOI":"10.1016\/S2214-109X(21)00299-0","article-title":"Economic impact of tuberculosis mortality in 120 countries and the cost of not achieving the Sustainable Development Goals tuberculosis targets: A full-income analysis","volume":"9","author":"Silva","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"ref_19","unstructured":"World Health Organization (2025, June 10). New WHO Recommendations to Prevent Tuberculosis Aim to Save Millions of Lives. Available online: https:\/\/www.who.int\/news\/item\/24-03-2020-new-who-recommendations-to-prevent-tuberculosis-aim-to-save-millions-of-lives."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Moodley, N., Saimen, A., Zakhura, N., Motau, D., Setswe, G., Charalambous, S., and Chetty-Makkan, C.M. (2020). They are inconveniencing us\u2019-exploring how gaps in patient education and patient centered approaches interfere with TB treatment adherence: Perspectives from patients and clinicians in the Free State Province, South Africa. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-08562-3"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100587","DOI":"10.1016\/j.ijregi.2025.100587","article-title":"Inequities underlie the alarming resurgence of Tuberculosis as the world\u2019s top cause of death from an Infectious Disease\u2014Breaking the silence and addressing the underlying root causes","volume":"19","author":"Zumla","year":"2025","journal-title":"IJID Reg."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Faye, L.M., Hosu, M.C., and Apalata, T. (2024). Drug-Resistant Tuberculosis in Rural Eastern Cape, South Africa: A Study of Patients\u2019 Characteristics in Selected Healthcare Facilities. Int. J. Environ. Res. Public. Health, 21.","DOI":"10.20944\/preprints202409.1682.v1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"728","DOI":"10.7196\/SAMJ.2019.v109i10.14073","article-title":"Figures of the dead: A decade of tuberculosis mortality registrations in South Africa","volume":"109","author":"Loveday","year":"2019","journal-title":"SAMJ S. Afr. Med. J."},{"key":"ref_24","first-page":"15","article-title":"Tuberculosis Knowledge, Attitudes, and Practice in Middle- and Low-Income Countries: A Systematic Review","volume":"1014666","author":"Craciun","year":"2023","journal-title":"J. Trop. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Abbas, R., Ali Salami, A., and Ghssein, G. (2025). Knowledge, Attitude, and Practices of Healthcare Workers Towards Tuberculosis, Multidrug-Resistant Tuberculosis, and Extensively Drug-Resistant Tuberculosis. Acta Microbiol. Hell., 70.","DOI":"10.3390\/amh70020012"},{"key":"ref_26","first-page":"100295","article-title":"Impacts of MDR\/XDR-TB on the global tuberculosis epidemic: Challenges and opportunities","volume":"7","author":"Chin","year":"2024","journal-title":"Curr. Res. Microb. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4046\/trd.2022.0148","article-title":"Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model","volume":"86","author":"Sazali","year":"2023","journal-title":"Tuberc. Respir. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s41043-021-00275-6","article-title":"Determinants of adherence to anti-TB treatment and associated factors among adult TB patients in Gondar city administration, Northwest, Ethiopia: Based on health belief model perspective","volume":"40","author":"Gebremariam","year":"2021","journal-title":"J. Health Popul. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.2147\/PPA.S222176","article-title":"Patient Perspectives on Factors Influencing Medication Adherence Among People with Coronary Heart Disease (CHD) and CHD Risk Factors","volume":"13","author":"Mondesir","year":"2019","journal-title":"Patient Prefer. Adherence"},{"key":"ref_30","unstructured":"Megan (2025, June 13). Three Aspects of Health and Healing: The Biopsychosocial Model in Medicine. Available online: https:\/\/surgery.wustl.edu\/three-aspects-of-health-and-healing-the-biopsychosocial-model\/."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1177\/0956462421992257","article-title":"HIV-associated tuberculosis","volume":"32","author":"Hamada","year":"2021","journal-title":"Int. J. STD AIDS."},{"key":"ref_32","unstructured":"Slovin, E. (2025, May 09). Slovin\u2019s Formula for Sampling Technique. Available online: https:\/\/www.scirp.org\/reference\/referencespapers?referenceid=2717038#."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1308\/003588413X13511609956372","article-title":"A quick guide to survey research","volume":"95","author":"Jones","year":"2013","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yang, H., Ruan, X., Li, W., Xiong, J., and Zheng, Y. (2024). Global, regional, and national burden of tuberculosis and attributable risk factors for 204 countries and territories, 1990\u20132021: A systematic analysis for the Global Burden of Diseases 2021 study. BMC Public Health, 4.","DOI":"10.1186\/s12889-024-20664-w"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12981-021-00365-9","article-title":"Determinant factors for adherence to antiretroviral therapy among adult HIV patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia: A case-control study","volume":"18","author":"Abdu","year":"2021","journal-title":"AIDS Res. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Nezenega, Z.S., Perimal-Lewis, L., and Maeder, A.J. (2020). Factors Influencing Patient Adherence to Tuberculosis Treatment in Ethiopia: A Literature Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17155626"},{"key":"ref_37","unstructured":"Soo, C.L., Pai, N.P., Bartlett, S.J., Esmail, A., Dheda, K., and Bhatnagar, S. (2023). Socioeconomic factors impact the risk of HIV acquisition in the township population of South Africa: A Bayesian analysis. PLoS Glob. Public Health, 26."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12981-022-00441-8","article-title":"The role of health facility and individual level characteristics on medication adherence among PLHIV on second-line antiretroviral therapy in Northeast Ethiopia: Use of multi-level model","volume":"19","author":"Wedajo","year":"2022","journal-title":"AIDS Res. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Adisa, R., Ayandokun, T.T., and Ige, O.M. (2021). Knowledge about tuberculosis, treatment adherence and outcome among ambulatory patients with drug-sensitive tuberculosis in two directly observed treatment centers in Southwest Nigeria. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-10698-9"},{"key":"ref_40","first-page":"67","article-title":"Medication adherence and its determinants among patients on concomitant tuberculosis and antiretroviral therapy in Southwest Ethiopia","volume":"4","author":"Kebede","year":"2022","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101795","DOI":"10.1016\/j.seps.2023.101795","article-title":"Patient adherence in healthcare operations: A narrative review","volume":"91","year":"2024","journal-title":"Socio-Econ. Plan. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40249-024-01221-4","article-title":"Discrepancies between self-reported medication in adherence and indirect measurement adherence among patients undergoing antiretroviral therapy: A systematic review","volume":"13","author":"Liao","year":"2024","journal-title":"Infect. Dis. Poverty"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1007\/s10461-019-02675-6","article-title":"Promoting Tuberculosis Preventive Therapy for People Living with HIV in South Africa: Interventions Hindered by Complicated Clinical Guidelines and Imbalanced Patient-Provider Dynamics","volume":"4","author":"Jarrett","year":"2020","journal-title":"AIDS Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"a1343","DOI":"10.4102\/sajhivmed.v23i1.1343","article-title":"Predictors of low antiretroviral adherence at an urban South African clinic: A mixed-methods study","volume":"23","author":"Bondarchuk","year":"2022","journal-title":"S. Afr. J. HIV Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Nidoi, J., Muttamba, W., Walusimbi, S., Imoko, J.F., Lochoro, P., Ictho, J., Mugenyi, L., Sekibira, R., Turyahabwe, S., and Byaruhanga, R. (2021). Impact of socio-economic factors on Tuberculosis treatment outcomes in north-eastern Uganda: A mixed methods study. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-12056-1"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40249-024-01230-3","article-title":"Epidemiological features and temporal trends of the co-infection between HIV and tuberculosis, 1990\u20132021: Findings from the Global Burden of Disease Study 2021","volume":"13","author":"Zhang","year":"2024","journal-title":"Infect. Dis. Poverty"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kamyab, A., Bijani, M., Jormand, H., Harsini, P.A., and Jeihooni, A.K. (2024). Education based on the theory of planned behavior to improve medication regimen adherence, hope and marital quality in patients with substance use disorder. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-20651-1"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Modisakeng, C., Matlala, M., Godman, B., and Meyer, J.C. (2020). Medicine shortages and challenges with the procurement process among public sector hospitals in South Africa; findings and implications. BMC Health Serv. Res., 20.","DOI":"10.1186\/s12913-020-05080-1"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1016\/j.ijtb.2024.03.011","article-title":"Socio-demographic factors & adherence of newly diagnosed pulmonary tuberculosis patients to the newly introduced daily regimen: A hospital survey based follow up study","volume":"71","author":"Shinde","year":"2024","journal-title":"Indian J. Tuberc."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Alinaitwe, B., Shariff, N.J., and Boddupalli, B.M. (2025). Treatment adherence and its association with family support among pulmonary tuberculosis patients in Jinja, Eastern Uganda. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-96260-8"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/22\/8\/1209\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:20:27Z","timestamp":1760034027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/22\/8\/1209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["ijerph22081209"],"URL":"https:\/\/doi.org\/10.3390\/ijerph22081209","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}