{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:23:17Z","timestamp":1792621397311,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan","award":["BR24993083"],"award-info":[{"award-number":["BR24993083"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Stigmatizing attitudes toward individuals with mental health conditions are common among healthcare professionals in primary healthcare (PHC) settings, posing a major barrier to early diagnosis, appropriate treatment, and recovery. Methods: This systematic review and meta-analysis evaluated the effectiveness of interventions aimed at reducing mental health-related stigma among PHC professionals (general practitioners, nurses, community health workers, and allied providers). Eligibility was restricted to interventional studies targeting PHC staff; non-clinical populations and students without clinical practice were excluded. Comparators included usual training, waitlist control, or pre\u2013post evaluation. A systematic search of PubMed, Scopus, and Web of Science was conducted in accordance with PRISMA guidelines, and the protocol was registered in PROSPERO (CRD420251074412). Results: Twenty-five studies met the inclusion criteria, of which three contributed to the quantitative synthesis. Interventions included educational, contact-based, and multicomponent approaches. Risk of bias was assessed using tools appropriate to study design. Interventions generally improved knowledge and attitudes and, to a lesser extent, behavioral intentions. Meta-analysis of pre\u2013post changes using the Opening Minds Scale for Health Care Providers (OMS-HC) demonstrated a significant reduction in stigma (MD = \u22120.27, 95% CI \u22120.40 to \u22120.14; p &lt; 0.001; I2 = 91%). A difference-in-differences analysis of studies with intervention and control groups confirmed this effect with moderate heterogeneity (MD = \u22120.18, 95% CI \u22120.25 to \u22120.11; p &lt; 0.0001; I2 = 50%). Conclusions: Contact-based and multicomponent interventions were associated with stronger and more sustained effects. The main limitations of the evidence were short follow-up periods, reliance on self-reported outcomes, methodological heterogeneity, and the possibility of publication bias. Our findings suggest that reducing stigma among PHC professionals can enhance patient engagement, timely diagnosis, and quality of care in routine clinical practice.<\/jats:p>","DOI":"10.3390\/ijerph22091441","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:00:00Z","timestamp":1758106800000},"page":"1441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Interventions to Reduce Mental Health Stigma Among Health Care Professionals in Primary Health Care: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-3651","authenticated-orcid":false,"given":"Lazzat","family":"Zhamaliyeva","sequence":"first","affiliation":[{"name":"Department of General Practice No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe 30012, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-2904","authenticated-orcid":false,"given":"Nurgul","family":"Ablakimova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Clinical Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4564-7418","authenticated-orcid":false,"given":"Assemgul","family":"Batyrova","sequence":"additional","affiliation":[{"name":"Department of Propedeutics of Internal Disease, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Veklenko","sequence":"additional","affiliation":[{"name":"Department of Propedeutics of Internal Disease, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-0498","authenticated-orcid":false,"given":"Andrej M.","family":"Grjibovski","sequence":"additional","affiliation":[{"name":"Reaviz Universtiy, Saint Petersburg 198095, Russia"},{"name":"Department of Epidemiology and Modern Vaccination Technologies, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"},{"name":"Department of Healthcare Organization and Preventive Medicine, North-Eastern Federal University, Yakutsk 677000, Russia"},{"name":"Department of Health Policy and Management, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-8089","authenticated-orcid":false,"given":"Sandugash","family":"Kudaibergenova","sequence":"additional","affiliation":[{"name":"Department of General and Applied Psychology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-3546","authenticated-orcid":false,"given":"Nursultan","family":"Seksenbayev","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addiction Medicine, Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"GBD 2019 Mental Disorders Collaborators (2022). 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