{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:36:49Z","timestamp":1765528609056,"version":"3.48.0"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["BR24992814"],"award-info":[{"award-number":["BR24992814"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Metabolic syndrome (MetS), a cluster of cardiometabolic abnormalities including elevated blood pressure, impaired glucose regulation, dyslipidemia, and increased waist circumference is increasingly recognized as a condition linked to both physical and psychological health risks. This study aims to investigate genotype-specific differences in psychological distress between healthy individuals and those with metabolic disorders, as well as to examine potential gene metabolic status interactions. Methods: This study is a cross-sectional analysis conducted in Turkistan city in the Southern region of Kazakhstan. Participants (healthy and those with metabolic syndrome) were invited to take part in the study by random sampling from the Khoja Akhmet Yassawi Kazakh-Turkish International University Medical Center. Consenting individuals provided a genetic analysis. Psychosomatic indicators were assessed using the Perceived Stress Questionnaire (PSQ) and the Depression, Anxiety, and Stress Scale (DASS-21). Results: A total of 200 individuals participated, with an approximately 3:1 ratio of women to men. The mean age in years was 50.4 \u00b1\u00a09.5 and 48.8 \u00b1\u00a07.7 for men and women, respectively. Preliminary analyses showed variations in cognitive and psychosomatic measures among individuals with metabolic syndrome, but no associations with genetic variants, and no significant group differences across key psychosomatic indicators when stratified by metabolic or genetic factors. However, a significant difference in LPL-Anxiety between genotypes GA-GG (p &lt; 0.05) was found. Conclusions: Variations in metabolic and genetic factors within the studied population were not associated with measurable differences in stress or depressive symptoms.<\/jats:p>","DOI":"10.3390\/ijerph22121853","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:30:17Z","timestamp":1765528217000},"page":"1853","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Predictors of Psychosomatic Symptoms in Individuals with Metabolic Syndrome: Insights from a Cross-Sectional Study in Kazakhstan"],"prefix":"10.3390","volume":"22","author":[{"given":"Dinara","family":"Nemetova","sequence":"first","affiliation":[{"name":"Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-672X","authenticated-orcid":false,"given":"Mira","family":"Zhunissova","sequence":"additional","affiliation":[{"name":"Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-3221","authenticated-orcid":false,"given":"Gulnaz","family":"Nuskabayeva","sequence":"additional","affiliation":[{"name":"Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-479X","authenticated-orcid":false,"given":"Ugilzhan","family":"Tatykayeva","sequence":"additional","affiliation":[{"name":"Department of Fundamental Medical Sciences, Faculty of Dentistry, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5655-5465","authenticated-orcid":false,"given":"Ainash","family":"Oshibayeva","sequence":"additional","affiliation":[{"name":"Department of Public Health and Research, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5341-7211","authenticated-orcid":false,"given":"Nursultan","family":"Nurdinov","sequence":"additional","affiliation":[{"name":"Department of Fundamental Medical Sciences, Faculty of Dentistry, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilbar","family":"Aidarbekova","sequence":"additional","affiliation":[{"name":"Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4263-8157","authenticated-orcid":false,"given":"Ainur","family":"Turmanbayeva","sequence":"additional","affiliation":[{"name":"Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-5209","authenticated-orcid":false,"given":"Yerbolat","family":"Saruarov","sequence":"additional","affiliation":[{"name":"Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanar","family":"Zhagiparova","sequence":"additional","affiliation":[{"name":"Faculty of Postgraduate Higher Medical Education, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-5763","authenticated-orcid":false,"given":"Yusuf","family":"Ozkul","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri 38039, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuriye","family":"Gokce","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri 38039, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-8565","authenticated-orcid":false,"given":"Karlygash","family":"Sadykova","sequence":"additional","affiliation":[{"name":"Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 161200, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/obr.12229","article-title":"Metabolic Syndrome: A Closer Look at the Growing Epidemic and Its Associated Pathologies","volume":"16","year":"2015","journal-title":"Obes. 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