{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:47Z","timestamp":1772118587005,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES","award":["88887.999621\/2024-00"],"award-info":[{"award-number":["88887.999621\/2024-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Background: Older adults with multiple myeloma (MM) contend with multifaceted physical, psychological, and existential challenges that may compromise quality of life (QoL). This study examined associations between physical symptom burden, functional capacity, depression severity, meaning in life, and QoL in older adults with MM. (2) Methods: Fifty outpatients (mean age = 67.7 \u00b1 8.8 years) completed the EORTC QLQ-C30, PHQ-9, and Meaning in Life Questionnaire (MLQ). QoL was the primary outcome. Secondary outcomes included physical symptom burden (fatigue and pain), functioning domains, depression severity, and meaning in life. Internal consistency of all instruments was satisfactory (Cronbach\u2019s \u03b1 &gt; 0.70). Analysis and associations among variables were done using Pearson\u2019s and Spearman\u2019s correlation coefficients (p &lt; 0.05). (3) Results: Participants reported high global QoL and preserved functioning. Fatigue and pain were most strongly associated with lower global QoL. Greater depression severeness, although mild, was correlated with higher physical symptom burden and poorer functioning. Higher Presence of Meaning was related to better QoL and lower depression severity, whereas Search for Meaning showed no significant associations. Women reported greater physical symptom burden than men. (4) Conclusions: In older adults with MM, QoL appears to be linked to interrelated physical, psychological, functional, and existential factors. Fatigue, pain, depression severity, and established meaning in life were identified as clinically relevant correlates, highlighting targets for integrated supportive care.<\/jats:p>","DOI":"10.3390\/ijerph23030289","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:58:03Z","timestamp":1772114283000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial Functioning, Quality of Life, Depressive Symptoms, and Meaning in Life in Older Adults with Multiple Myeloma: A Cross-Sectional Study"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-0158","authenticated-orcid":false,"given":"\u00c9rika Arantes","family":"Oliveira-Cardoso","sequence":"first","affiliation":[{"name":"Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4329-102X","authenticated-orcid":false,"given":"Virginia Comazzetto","family":"Tabuzo","sequence":"additional","affiliation":[{"name":"Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit\u00f3ria Fernandes","family":"Andreossi","sequence":"additional","affiliation":[{"name":"Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ant\u00f4nia Souza","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4823-7157","authenticated-orcid":false,"given":"Jorge Henrique Corr\u00eaa","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Santos","family":"Lot\u00e9rio","sequence":"additional","affiliation":[{"name":"Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-6932","authenticated-orcid":false,"given":"Pedro Manoel Marques","family":"Garibaldi","sequence":"additional","affiliation":[{"name":"Hemocentro Hospital, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14051-140, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel Ayrosa","family":"Madeira","sequence":"additional","affiliation":[{"name":"Hemocentro Hospital, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14051-140, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-7767","authenticated-orcid":false,"given":"Manoel Ant\u00f4nio","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1055\/s-0043-1770149","article-title":"Multiple Myeloma (Part 1): Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis","volume":"58","author":"Guedes","year":"2023","journal-title":"Rev. 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