{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:11:47Z","timestamp":1787807507745,"version":"build-2784847793"},"reference-count":71,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Smith\u2014Revealing Reservoirs during Rebound (R3) Last Gift, Early Treatment Interruption","award":["P01 AI131385"],"award-info":[{"award-number":["P01 AI131385"]}]},{"DOI":"10.13039\/100000060","name":"Smith\u2014Leaving, Coming and Staying HIV Obligate Microenvironments","doi-asserted-by":"publisher","award":["P01 AI169609"],"award-info":[{"award-number":["P01 AI169609"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BEAT-HIV Collaboratory","award":["UM1AI164570"],"award-info":[{"award-number":["UM1AI164570"]}]},{"name":"San Diego Center for AIDS Research","award":["P30 AI036214"],"award-info":[{"award-number":["P30 AI036214"]}]},{"name":"National Institute on Aging T35","award":["AG026757"],"award-info":[{"award-number":["AG026757"]}]},{"name":"Stein Institute for Research on Aging at the University of California, San Diego"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Introduction: End-of-life (EOL) HIV cure-related research offers a unique opportunity to advance scientific discovery while honoring the values, dignity, and legacy of people with HIV. However, participation remains demographically skewed, mirroring long-standing inequities in who is informed, invited, and supported to take part. Synthesizing eight years of experience, published literature reviews, and community engagement from the University of California San Diego\u2019s Last Gift program, we propose strategies to embed justice, equity, diversity, inclusion, and accessibility (JEDIA) throughout the design and implementation of EOL HIV cure-related studies. Discussion: Using intersectionality as a structural analytic framework, we examine how interlocking systems and social determinants shape access, consent, and participant experience, and we translate ethics into action across three themes and eight domains. As examples, we facilitate equitable access by implementing solutions that address gaps limiting awareness and feasibility of participation. We establish ongoing consent through multi-session consent processes with teach-back methods, clear healthcare proxy pathways, and explicit separation of research activities from clinical care. We center lived experiences by partnering with people with HIV and community groups, customizing participation, and honoring cultural and spiritual needs. We enable real-time course correction by using a dashboard that monitors enrollment patterns and representation. Conclusions: An intersectionality-informed, participant-centered approach is both feasible and essential to ensure HIV cure-related research advances with fairness, trust, and global relevance. Programs such as the Last Gift show that scientific rigor, integrity, and participant dignity can coexist, establishing a model for equitable HIV cure discovery.<\/jats:p>","DOI":"10.3390\/ijerph23030295","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:41:02Z","timestamp":1772188862000},"page":"295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intersectionality-Informed HIV Cure-Related Research at the End of Life: A Call to Action"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-1853","authenticated-orcid":false,"given":"Ali","family":"Ahmed","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Shelton","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Tennessee Knoxville, Knoxville, TN 37996, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6288-7619","authenticated-orcid":false,"given":"Malachi P.","family":"Keo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital of Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-2513","authenticated-orcid":false,"given":"Kris H.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-537X","authenticated-orcid":false,"given":"Alejandra","family":"Mortlett-Paredes","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel O.","family":"Ndukwe","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Taylor","sequence":"additional","affiliation":[{"name":"HIV+ Aging Research Project\u2014Palm Springs, Palm Springs, CA 92264, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-4200","authenticated-orcid":false,"given":"Thomas J.","family":"Villa","sequence":"additional","affiliation":[{"name":"HOPE Martin Delaney Collaboratory for HIV Cure Research Community Engagement, Washinton, DC 20004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgette","family":"Picou","sequence":"additional","affiliation":[{"name":"The Well Project, Palm Springs, CA 92262, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie D.","family":"Matherne","sequence":"additional","affiliation":[{"name":"Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2558-7425","authenticated-orcid":false,"given":"Renato","family":"Bobadilla-Leon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lau","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Solso","sequence":"additional","affiliation":[{"name":"AntiViral Research Center (AVRC), University of California San Diego (UCSD), San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Dullano","sequence":"additional","affiliation":[{"name":"AntiViral Research Center (AVRC), University of California San Diego (UCSD), San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davey","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-3857","authenticated-orcid":false,"given":"Antoine","family":"Chaillon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Deiss","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gianella","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Dub\u00e9","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health (IDGPH), School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, 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