{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:08:57Z","timestamp":1775624937544,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100027162","name":"Society to Improve Diagnosis in Medicine","doi-asserted-by":"crossref","award":["640"],"award-info":[{"award-number":["640"]}],"id":[{"id":"10.13039\/100027162","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mayo Clinic Department of Medicine, Division of General Internal Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Despite the increasing prevalence and median severity of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS), medical education on the disease is scant, leading to a diagnostic crisis in which the majority of people with ME\/CFS are undiagnosed. We created a care process algorithm in AskMayoExpert accessible to all Mayo Clinic medical providers as a source for information on diagnosis and management of ME\/CFS. To evaluate whether the algorithm was associated with improved diagnostic accuracy, we compared concordance before versus after the algorithm was introduced, where concordance was defined as agreement between an appropriately coded referral to Mayo Clinic\u2019s Chronic Fatigue Specialty Clinic and the specialty clinic with an expert diagnosis of ME\/CFS. Referrals to the Chronic Fatigue Specialty Clinic increased overall and were more likely to show concordance between specialist diagnosis and referral after the introduction of the ME\/CFS AskMayoExpert algorithm. Particularly in diseases that are prevalent and poorly understood, a point-of-care clinical tool may offer just-in-time opportunities to improve diagnosis and management.<\/jats:p>","DOI":"10.3390\/ijerph23040460","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:10:27Z","timestamp":1775448627000},"page":"460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improving Diagnostic Accuracy of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome Through a Point-of-Care Clinical Algorithm"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-3585","authenticated-orcid":false,"given":"Jaime","family":"Seltzer","sequence":"first","affiliation":[{"name":"The Myalgic Encephalomyelitis Action Network, Santa Clara, CA 90403, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-6219","authenticated-orcid":false,"given":"Stephanie L.","family":"Grach","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-1054","authenticated-orcid":false,"given":"Scott D.","family":"Eggers","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Redetzke","sequence":"additional","affiliation":[{"name":"Health Education and Content Services, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie J.","family":"Mau","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony Y.","family":"Chon","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA"},{"name":"Baptist Health Medical Group, Baptist Health Quality Network, Miami, FL 33143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"ref_1","unstructured":"WHO (1969). 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