{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:17:55Z","timestamp":1785403075546,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technology and innovation","award":["112291891873"],"award-info":[{"award-number":["112291891873"]}]},{"name":"Ministry of Science, Technology and innovation","award":["655\/2022"],"award-info":[{"award-number":["655\/2022"]}]},{"award":["112291891873"],"award-info":[{"award-number":["112291891873"]}],"id":[{"id":"https:\/\/ror.org\/03fd5ne08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["655\/2022"],"award-info":[{"award-number":["655\/2022"]}],"id":[{"id":"https:\/\/ror.org\/03fd5ne08","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Alcohol and psychoactive substance use represent a major burden for global public health, increasing the risk of non-communicable diseases, violence, road traffic injuries, dependence, and mental disorders, and generating impacts on productivity and social welfare. This study aimed to estimate the burden of disease attributable to alcohol and other psychoactive substances in the departments of Colombia from 2016 to 2022. A burden-of-disease study was conducted using the Disability-Adjusted Life Years (DALYs) indicator, following the methodology of the World Health Organization Global Health Estimates. Official morbidity and mortality databases were used. An estimated 236,154.42 DALYs were attributable to alcohol and psychoactive substance use in Colombia during the study period, increasing from 14,158.7 DALYs in 2016 to 40,190.7 DALYs in 2022. The burden was heterogeneous across departments, with values above 1000 DALYs in Quind\u00edo (1779.5), Nari\u00f1o (1624.3), and Norte de Santander (1008.0) and below 132 DALYs in La Guajira, Casanare, and Vaup\u00e9s. Men accounted for 73.5% of total DALYs. The mean age of morbidity records associated with alcohol and psychoactive substance use disorders was 30.67 years in men and 32.37 years in women. The burden associated with psychoactive substance use is increasing in Colombia, with differences by sex and department of residence.<\/jats:p>","DOI":"10.3390\/ijerph23050659","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:46:18Z","timestamp":1779381978000},"page":"659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden of Disease Due to Consumption of Alcohol and Other Drugs in Colombia, 2016\u20132022: A Subnational Regional Analysis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5181-0236","authenticated-orcid":false,"given":"Oscar Alexander","family":"Guti\u00e9rrez-Lesmes","sequence":"first","affiliation":[{"name":"School of Public Health, Universidad de los Llanos, Villavicencio 500001, Meta, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilce","family":"Salamanca Ramos","sequence":"additional","affiliation":[{"name":"Gesi Research Group, School of Public Health, Universidad de los Llanos, Villavicencio 500001, Meta, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Julieth","family":"Quintero D\u00edaz","sequence":"additional","affiliation":[{"name":"School of Public Health, Universidad de los Llanos, Villavicencio 500001, Meta, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, T., Sun, L., Yin, X., Chen, H., Yang, L., and Yang, X. (2024). Burden of drug use disorders in the United States from 1990 to 2021 and its projection until 2035: Results from the GBD study. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-19142-0"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"GBD 2016 Alcohol and Drug Use Collaborators (2018). The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Psychiatry, 5, 987\u20131012.","DOI":"10.1016\/S2215-0366(18)30337-7"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112495","DOI":"10.1016\/j.drugalcdep.2024.112495","article-title":"The burden of alcohol and substance use disorders in adolescents and young adults","volume":"266","author":"Danpanichkul","year":"2025","journal-title":"Drug Alcohol Depend."},{"key":"ref_4","first-page":"13","article-title":"El consumo de sustancias psicoactivas y su influencia en el desarrollo integral","volume":"4","author":"Piedra","year":"2020","journal-title":"J. Bus. Entrep. Stud."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bardach, A.E., Alcaraz, A.O., Ciapponi, A., Garay, O.U., Riviere, A.P., Palacios, A., Cremonte, M., and Augustovski, F. (2019). Alcohol consumption\u2019s attributable disease burden and cost-effectiveness of targeted public health interventions: A systematic review of mathematical models. BMC Public Health, 19.","DOI":"10.1186\/s12889-019-7771-4"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.amepre.2022.03.025","article-title":"Alcohol Consumption and 15 Causes of Fatal Injuries: A Systematic Review and Meta-Analysis","volume":"63","author":"Alpert","year":"2022","journal-title":"Am. J. Prev. Med."},{"key":"ref_7","unstructured":"GBD 2016 Alcohol Collaborators (2018). Alcohol use and burden for 195 countries and territories, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 392, 1015\u20131035."},{"key":"ref_8","unstructured":"World Health Organization (2018). Global Status Report on Alcohol and Health 2018, World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241565639."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e093412","DOI":"10.1136\/bmjopen-2024-093412","article-title":"Global burden attributed to alcohol and drug use among adolescents and young adults, 1990\u20132019: Results from the Global Burden of Disease Study 2019","volume":"15","author":"Li","year":"2025","journal-title":"BMJ Open"},{"key":"ref_10","unstructured":"Institute for Health Metrics and Evaluation (IHME) (2020). Global Burden of Disease Study 2019 (GBD 2019) Results, Institute for Health Metrics and Evaluation (IHME). Available online: https:\/\/vizhub.healthdata.org\/gbd-results\/."},{"key":"ref_11","first-page":"85","article-title":"Burden of disease due to amphetamines, cannabis, cocaine, and opioid use disorders in South America, 1990-2019: A systematic analysis of the Global Burden of Disease Study 2019","volume":"10","author":"Wang","year":"2023","journal-title":"Lancet"},{"key":"ref_12","unstructured":"Ministry of Justice, Law\u2014Drug Observatory of Colombia, National Forensics Institute (2025, August 18). Mortality Study Associated with the Consumption of Psychoactive Substances 2013\u20132020, Available online: https:\/\/www.odc.gov.co."},{"key":"ref_13","unstructured":"Ministerio de Justicia y del Derecho, Observatorio de Drogas de Colombia, Oficina de las Naciones Unidas Contra la Droga y el Delito (2025, August 18). Bolet\u00edn T\u00e9cnico\u2014Encuesta Nacional de Consumo de Sustancias Psicoactivas (ENCSPA) 2019, Available online: https:\/\/www.dane.gov.co\/files\/investigaciones\/boletines\/encspa\/bt-encspa-2019.pdf."},{"key":"ref_14","unstructured":"Department of Data and Analytics Division of Data Analytics and Delivery for Impact WHO (2024). WHO Methods and Data Sources for Global Burden of Disease Estimates 2000\u20132021, Department of Data and Analytics Division of Data Analytics and Delivery for Impact WHO. Available online: https:\/\/cdn.who.int\/media\/docs\/default-source\/gho-documents\/global-health-estimates\/ghe2021_daly_methods.pdf."},{"key":"ref_15","unstructured":"World Health Organization (2020). WHO Methods and Data Sources for Global Burden of Disease Estimates 2000\u20132019, World Health Organization. Available online: https:\/\/cdn.who.int\/media\/docs\/default-source\/gho-documents\/global-health-estimates\/ghe2019_daly-methods.pdf."},{"key":"ref_16","unstructured":"Ministerio de Salud de Colombia (2025, August 18). Resoluci\u00f3n 8430 de 1993, Por la Cual se Establecen las Normas Cient\u00edficas, T\u00e9cnicas y Administrativas Para la Investigaci\u00f3n en Salud, Available online: https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/DE\/DIJ\/RESOLUCION-8430-DE-1993.PDF."},{"key":"ref_17","unstructured":"Council for International Organizations of Medical Sciences (CIOMS) (2016). International Ethical Guidelines for Health-Related Research Involving Humans, Council for International Organizations of Medical Sciences (CIOMS). Available online: https:\/\/cioms.ch\/publications\/product\/international-ethical-guidelines-for-health-related-research-involving-humans\/."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"GBD 2019 Mental Disorders Collaborators (2022). Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry, 9, 137\u2013150.","DOI":"10.1016\/S2215-0366(21)00395-3"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Quintero D\u00edaz, K.J., Gutierrez Lesmes, O.A., and Salamanca Ramos, E. (2025). Burden of Mental and Behavioral Disorders in Colombia, 2022: A Subnational Analysis Based on Disability-Adjusted Life Years. Int. J. Environ. Res. Public Health, 22.","DOI":"10.3390\/ijerph22121854"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/eurpub\/ckab124","article-title":"Stronger alcohol-violence association when adolescents drink less? Evidence from three Nordic countries","volume":"31","author":"Moan","year":"2021","journal-title":"Eur. J. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100724","DOI":"10.1016\/j.bbih.2024.100724","article-title":"Use of psychoactive substances among university students from 2019 to 2020: A systematic review","volume":"35","author":"Sampaio","year":"2024","journal-title":"Brain Behav. Immun.-Health"},{"key":"ref_22","unstructured":"Observatorio de Drogas de Colombia, Ministerio de Justicia y del Derecho (2025, October 02). Estudio Nacional de Consumo de Sustancias Psicoactivas en Poblaci\u00f3n Escolar, Colombia 2016, Available online: https:\/\/www.minjusticia.gov.co\/programas-co\/ODC\/Publicaciones\/Publicaciones\/CO03142016_estudio_consumo_escolares_2016.pdf."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bero\u00edza-Valenzuela, F. (2024). The challenges of mental health in Chilean university students. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1297402"},{"key":"ref_24","unstructured":"Gobernaci\u00f3n de Antioquia, Secretar\u00eda Seccional de Salud y Protecci\u00f3n Social de Antioquia, Escuela Contra la Drogadicci\u00f3n, ASCODES SAS (2025, October 02). Estudio de Consumo de Sustancias Psicoactivas para el Departamento de Antioquia, sus Subregiones y Medell\u00edn\u20142021, Available online: https:\/\/es.scribd.com\/document\/750056703\/Estudio-Antioquia-de-consumo-de-SPA-2021."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.rpsm.2021.06.005","article-title":"The burden of mental disorders in Mexico, 1990-2019: Mental and neurological disorders, substance use, suicides, and related somatic disorders","volume":"17","author":"Ortega","year":"2024","journal-title":"Span. J. Psychiatry Ment. Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Murray","year":"2020","journal-title":"Lancet"},{"key":"ref_27","unstructured":"Secretar\u00eda Distrital de Salud de Bogot\u00e1, Observatorio de Salud de Bogot\u00e1\u2014SaluData (2026, February 03). Prevalencia Consumo Actual de Bebidas Alcoh\u00f3licas, Tabaco, Sustancias Il\u00edcitas en Bogot\u00e1, D.C., 2016\u20132022, Available online: https:\/\/saludata.saludcapital.gov.co\/osb\/indicadores\/prevalencia-consumo-actual\/."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/acer.14689","article-title":"Global estimates of the attributable risk of alcohol consumption on road injuries","volume":"45","author":"Borges","year":"2021","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_29","unstructured":"Congreso de Colombia (2026, February 03). Ley 1581 de 2012\u2014Ley de Protecci\u00f3n de Datos Personales 2012, Available online: https:\/\/www.funcionpublica.gov.co\/eva\/gestornormativo\/norma_pdf.php?i=49981."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/23\/5\/659\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:29:57Z","timestamp":1779424197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/23\/5\/659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ijerph23050659"],"URL":"https:\/\/doi.org\/10.3390\/ijerph23050659","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]}}}