{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:04:15Z","timestamp":1784880255796,"version":"3.55.0"},"reference-count":37,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Environ. Res. Public Health","IJERPH"],"abstract":"<jats:p>Metabolic syndrome is a major public health concern, yet evidence from structured community-based interventions in Latin America remains limited. This study conducted a comparative reanalysis of an 18-week program implemented in Talca, Chile, that combined supervised aerobic exercise, health education, and clinical monitoring. The analysis included archived data from 80 adults with metabolic syndrome who had originally been randomly allocated using SPSS to an intervention group (n=33) or a usual-care comparison group (n=47). Anthropometric, biochemical, cardiovascular, body-composition, functional-capacity, and estimated cardiorespiratory-fitness outcomes were assessed at baseline and after 18 weeks. At the post-intervention assessment, the intervention group showed greater Six-Minute Walk Test (6MWT) distance, higher 6MWT-based estimates of cardiorespiratory fitness, lower waist circumference, systolic and diastolic blood pressure, fasting glucose, triglycerides, body weight, body fat percentage, and fat mass, and higher high-density lipoprotein (HDL) cholesterol and muscle mass percentage than the comparison group. Within the intervention group, body weight, body fat percentage, and fat mass decreased, whereas muscle mass and 6MWT distance increased. These findings indicate that participation in the integrated program was associated with favorable cardiometabolic, body-composition, and functional outcomes. The results support further prospective evaluation of this community-based model within primary healthcare and public health settings.<\/jats:p>","DOI":"10.3390\/ijerph23080955","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:36:13Z","timestamp":1784878573000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Community-Based Non-Pharmacological Intervention for Metabolic Syndrome in Chile: A Comparative Reanalysis of an Integrated Exercise and Health Education Program"],"prefix":"10.3390","volume":"23","author":[{"given":"Guillermo","family":"Medina-Santos","sequence":"first","affiliation":[{"name":"Facultad de Salud y Servicios Sociales, Universidad Estatal de Milagro (UNEMI), Milagro 091002, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Urz\u00faa","sequence":"additional","affiliation":[{"name":"Escuela de Kinesiolog\u00eda, Facultad de Salud, Universidad Santo Tom\u00e1s, Campus Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3925-170X","authenticated-orcid":false,"given":"Jorge","family":"M\u00e9ndez-Cornejo","sequence":"additional","affiliation":[{"name":"Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Cat\u00f3lica del Maule, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-3827","authenticated-orcid":false,"given":"Edgardo","family":"Rojas-Mancilla","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez OECI Cancer Center, Laboratorio Cl\u00ednico, Santiago 7500000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-0705","authenticated-orcid":false,"given":"Carmen","family":"Zambrano-Bravo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias del Movimiento Humano, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"O\u00f1ate-Henr\u00edquez","sequence":"additional","affiliation":[{"name":"Departamento de Ergonom\u00eda, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinidad","family":"Parada","sequence":"additional","affiliation":[{"name":"Servicio Local De Educaci\u00f3n P\u00fablica Los Alamos, Linares 3580000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Vidal-Silva","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda y Negocios, Universidad de Las Am\u00e9ricas, Manuel Montt 948, Santiago 7500975, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41572-024-00563-5","article-title":"Metabolic syndrome","volume":"10","author":"Neeland","year":"2024","journal-title":"Nat. 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