{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T20:50:14Z","timestamp":1761252614883,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T00:00:00Z","timestamp":1257206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We aimed to provide a summary of the existing published knowledge on the association between adverse birth outcomes and the development of wheezing during the first two years of life. We carried out a systematic review of epidemiological studies within the MEDLINE database. Epidemiological studies on human subjects, published in English, were included in the review. A comprehensive literature search yielded 72 studies for further consideration. Following the application of the eligibility criteria we identified nine studies. A positive association and an excess risk of wheezing during the first two years of life were revealed for adverse birth outcomes.<\/jats:p>","DOI":"10.3390\/ijerph6112752","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T02:31:33Z","timestamp":1257301893000},"page":"2752-2761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review"],"prefix":"10.3390","volume":"6","author":[{"given":"Evridiki","family":"Patelarou","sequence":"first","affiliation":[{"name":"University Hospital of Heraklion, Crete, 71414 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Chochlidaki","sequence":"additional","affiliation":[{"name":"Independent Researcher, Crete, Heraklion, 71500 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Vivilaki","sequence":"additional","affiliation":[{"name":"Department of Midwifery, Technological Educational Institution, Athens, 12210 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hero","family":"Brokalaki","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, University of Athens, 11527 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2009,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1164\/ajrccm\/142.3.555","article-title":"Predictors of asthma and persistent wheeze in a national sample of children in the United States","volume":"142","author":"Schwartz","year":"1990","journal-title":"Am. 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