{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:41:58Z","timestamp":1772628118839,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T00:00:00Z","timestamp":1268870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The goal of this report is to assess the relationship of varying levels of blood alcohol concentration (BAC) and hospital complications in patients admitted after motor vehicle crashes. Data for the study was collected by a retrospective review of the University of Wisconsin Hospital trauma registry between 1999 and 2007 using the National Trauma Registry of the American College of Surgeons (NTRACS). Of 3729 patients, 2210 (59%) had a negative BAC, 338 (9%) 200 mg\/dL. Forty-six percent of patients had one or more hospital related complications. The odds ratio (OR) for the occurrence of alcohol withdrawal in the three alcohol groups compared to the no alcohol group was 12.02 (CI 7.0\u201320.7), 16.81 (CI 10.4\u201327.2), and 30.96 (CI 19.5\u201349.2) as BAC increased with a clear dose response effect. While there were no significant differences in the frequency of the total hospital events following trauma across the four groups, rates of infections, coagulopathies, central nervous system events and renal complications were lower in the high BAC group. Prospective studies are needed to more precisely estimate the frequency of hospital complications in patients with alcohol use disorders and in persons intoxicated at the time of the motor vehicle accident. The study supports the use of routine BAC to predict patients at high risk for alcohol withdrawal and the early initiation of alcohol detoxification.<\/jats:p>","DOI":"10.3390\/ijerph7031174","type":"journal-article","created":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T12:28:26Z","timestamp":1268915306000},"page":"1174-1185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Can the Blood Alcohol Concentration Be a Predictor for Increased Hospital Complications in Trauma Patients Involved in Motor Vehicle Crashes?"],"prefix":"10.3390","volume":"7","author":[{"given":"Jaime H.","family":"Kapur","sequence":"first","affiliation":[{"name":"University of Wisconsin Department of Surgery, Clinical Science Center H4\/7, 600 Highland Ave, Madison, WI 53792, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Rajamanickam","sequence":"additional","affiliation":[{"name":"University of Wisconsin Department of Surgery Biostatistiscs, 5105 Wisconsin Institutes for Medical Research (WIMR) Building 1485, 1111 Highland Avenue, Madison, WI 53792, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Fleming","sequence":"additional","affiliation":[{"name":"University of Wisconsin Department of Family Medicine, UW Department of Family Medicine 1100 Delaplaine Ct., Madison, WI 53715, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2010,3,18]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention WISQAR databaseNon-Fatal Injury Reports: 2001\u22122007Available online: http:\/\/www.cdc.gov\/injury\/wisqars\/index.html (accessed in April 2009)."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.aap.2005.04.013","article-title":"Drug and alcohol use among drivers admitted to a Level-1 trauma center","volume":"37","author":"Michael","year":"2005","journal-title":"Accid. Anal. Prev"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.15288\/jsad.2008.69.218","article-title":"Acute alcohol consumption and injury: risk associations and attributable fractions for different injury mechanisms","volume":"69","author":"Kuendig","year":"2008","journal-title":"J. Stud. Alcohol. Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0001-4575(97)00051-1","article-title":"Crash characteristics and injuries of victims impaired by alcohol versus illicit drugs","volume":"29","author":"Waller","year":"1997","journal-title":"Accid. Anal. Prev"},{"key":"ref_5","first-page":"27","article-title":"The effects of alcohol on in-hospital mortality in drivers admitted after motor vehicle accidents","volume":"66","author":"Koval","year":"2008","journal-title":"Bull. NYU Hosp. Jt. Dis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0001-4575(93)90070-D","article-title":"Alcohol and drug use among motor vehicle collision victims admitted to a regional trauma unit: demographic, injury, and crash characteristics","volume":"25","author":"Stoduto","year":"1993","journal-title":"Accid. Anal. Prev"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/00007611-199208000-00003","article-title":"Comparability of alcohol and drug use in injured drivers","volume":"85","author":"Kirby","year":"1992","journal-title":"South. Med. J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0196-0644(94)70162-8","article-title":"The impaired driver: hospital and police detection of alcohol and other drugs of abuse in motor vehicle crashes","volume":"24","author":"Orsay","year":"1994","journal-title":"Ann. Emerg. Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0001-4575(00)00091-9","article-title":"Alcohol\/drug abuse, driving convictions, and risk-taking dispositions among trauma center patients","volume":"33","author":"Soderstrom","year":"2001","journal-title":"Accid. Anal. Prev"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1300\/J069v26n02_07","article-title":"Sociodemographic characteristics associated with substance use status in a trauma inpatient population","volume":"26","author":"Martins","year":"2007","journal-title":"J. Addict. Dis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1553-2712.1997.tb03545.x","article-title":"Alcohol abuse\/dependence in motor vehicle crash victims presenting to the emergency department","volume":"4","author":"Maio","year":"1997","journal-title":"Acad. Emerg. Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1530-0277.2002.tb02429.x","article-title":"Brief physician advice for problem drinkers: long-term efficacy and benefit-cost analysis","volume":"26","author":"Fleming","year":"2002","journal-title":"Alcohol. Clin. Exp. Res"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/01.sla.0000157133.80396.1c","article-title":"Alcohol interventions for trauma patients treated in emergency departments and hospitals: a cost benefit analysis","volume":"241","author":"Gentilello","year":"2005","journal-title":"Ann. Surg"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1553-2712.1998.tb02505.x","article-title":"Epidemiology of alcohol-related emergency department visits","volume":"5","author":"Li","year":"1998","journal-title":"Acad. Emerg. Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/00005373-198408000-00001","article-title":"The influence of ethanol intoxication on outcome of injured motorcyclists","volume":"24","author":"Luna","year":"1984","journal-title":"J. Trauma"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1001\/jama.1986.03380110067028","article-title":"The potentiating effects of alcohol on driver injury","volume":"256","author":"Waller","year":"1986","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/ajem.2003.50025","article-title":"Alcohol intoxication increases morbidity in drivers involved in motor vehicle accidents","volume":"21","author":"Shih","year":"2003","journal-title":"Am. J. Emerg. Med"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/00005373-198306000-00009","article-title":"Effect of acute ethanolism on the hospital course and outcome of injured automobile drivers","volume":"23","author":"Huth","year":"1983","journal-title":"J. Trauma"},{"key":"ref_19","first-page":"429","article-title":"Does acute alcohol ingestion and\/or chronic alcohol use among motor vehicle crash victims lead to a more complicated hospital course?","volume":"44","author":"Melnick","year":"2000","journal-title":"Annu. Proc. Assoc. Adv. Automot. Med"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1300\/J069v14n01_05","article-title":"Alcohol use and injury severity in trauma patients","volume":"14","author":"Fuller","year":"1995","journal-title":"J. Addict. Dis"},{"key":"ref_21","first-page":"755","article-title":"Increased incidence of complications in trauma patients cointoxicated with alcohol and other drugs","volume":"62","author":"Rootman","year":"2007","journal-title":"J. Trauma"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00005373-200103000-00018","article-title":"Blood alcohol concentration and management of road trauma patients in the emergency department","volume":"50","author":"Fabbri","year":"2001","journal-title":"J. Trauma"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1993.03510010057029","article-title":"The effect of acute alcohol intoxication and chronic alcohol abuse on outcome from trauma","volume":"270","author":"Jurkovich","year":"1993","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/01.ta.0000245981.22931.43","article-title":"Alcohol withdrawal syndrome: Turning minor injuries into a major problem","volume":"61","author":"Bard","year":"2006","journal-title":"J Trauma"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0002-9610(82)90617-1","article-title":"Effects of ethanol ingestion on the severity and outcome of trauma","volume":"144","author":"Ward","year":"1982","journal-title":"Am. J. Surg"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1530-0277.2003.tb04407.x","article-title":"Alcohol effects on motor vehicle crash injury","volume":"27","author":"Waller","year":"2003","journal-title":"Alcohol. Clin. Exp. Res"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.amjsurg.2003.12.027","article-title":"Admission characteristics of trauma patients in whom delirium develops","volume":"187","author":"Blondell","year":"2004","journal-title":"Am. J. Surg"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.amjsurg.2008.07.037","article-title":"Risk factors for delirium after major trauma","volume":"196","author":"Angles","year":"2008","journal-title":"Am J Surg"},{"key":"ref_29","first-page":"34","article-title":"Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients","volume":"65","author":"Pandharipande","year":"2008","journal-title":"J. Trauma"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"192A","DOI":"10.1111\/j.1530-0277.1996.tb01774.x","article-title":"Effects of ethanol consumption on susceptibility to pulmonary and gastrointestinal factors","volume":"20","author":"Mellencamp","year":"1996","journal-title":"Alcohol. Clin. Exp. Res"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-4899-1742-3_15","article-title":"Recent developments in alcoholism:immunological aspects","volume":"11","author":"Baker","year":"1993","journal-title":"Recent Dev. Alcohol"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.alcohol.2008.12.006","article-title":"Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society","volume":"43","author":"Bird","year":"2009","journal-title":"Alcohol"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0025-6196(11)65025-8","article-title":"Detectable blood alcohol after a motor vehicle crash and screening for alcohol abuse\/dependence","volume":"75","author":"Maxson","year":"2000","journal-title":"Mayo Clin. Proc"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.genhosppsych.2003.08.007","article-title":"Hospitalized patients and alcohol: who is being missed?","volume":"26","author":"Bostwick","year":"2004","journal-title":"Gen. Hosp. Psychiat"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00005373-200211000-00015","article-title":"Risk factors for delirium tremens in trauma patients","volume":"53","author":"Lukan","year":"2002","journal-title":"J. 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