{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:08:12Z","timestamp":1781510892584,"version":"3.54.1"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T00:00:00Z","timestamp":1313452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The purpose of this study was to conduct a literature review of cost-benefit studies on pharmacotherapy and psychotherapy treatments of alcohol dependence (AD). A literature search was performed in multiple electronic bibliographic databases. The search identified seven psychotherapy studies from the USA and two pharmacotherapy studies from Europe. In the psychotherapy studies, major benefits are typically seen within the first six months of treatment. The benefit-cost ratio ranged from 1.89 to 39.0. Treatment with acamprosate was found to accrue a net benefit of 21,301 BEF (528 \u20ac) per patient over a 24-month period in Belgium and lifetime benefit for each patient in Spain was estimated to be Pta. 3,914,680 (23,528 \u20ac). To date, only a few studies exist that have examined the cost-benefit of psychotherapy or pharmacotherapy treatment of AD. Most of the available treatment options for AD appear to produce marked economic benefits.<\/jats:p>","DOI":"10.3390\/ijerph8083351","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T10:29:17Z","timestamp":1313490557000},"page":"3351-3364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Literature Review of Cost-Benefit Analyses for the Treatment of Alcohol Dependence"],"prefix":"10.3390","volume":"8","author":[{"given":"Svetlana","family":"Popova","sequence":"first","affiliation":[{"name":"Social and Epidemiological Research Department, Centre for Addiction and Mental Health, 33 Russell St., Toronto, Ontario M5S 2S1, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 3M7, Canada"},{"name":"Factor-Inwentash Faculty of Social Work, University of Toronto, 246 Bloor St. West, Toronto, Ontario M5S 1V4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Social and Epidemiological Research Department, Centre for Addiction and Mental Health, 33 Russell St., Toronto, Ontario M5S 2S1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayadeep","family":"Patra","sequence":"additional","affiliation":[{"name":"Social and Epidemiological Research Department, Centre for Addiction and Mental Health, 33 Russell St., Toronto, Ontario M5S 2S1, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 3M7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Duhig","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Global Health Outcomes, Indianapolis, IN 46285, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Rehm","sequence":"additional","affiliation":[{"name":"Social and Epidemiological Research Department, Centre for Addiction and Mental Health, 33 Russell St., Toronto, Ontario M5S 2S1, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 3M7, Canada"},{"name":"Klinische Psychologie und Psychotherapie, Epidemiological Research Unit, Technische Universit\u00e4t, Hohe Street 53, Dresden D-01187, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/alcalc\/agl081","article-title":"Examining treatment use among alcohol-dependent individuals from a population perspective","volume":"41","author":"Cunningham","year":"2006","journal-title":"Alcohol Alcohol"},{"key":"ref_2","first-page":"711","article-title":"Can encouraging substance abuse patients to participate in self-help groups reduce demand for health care? 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