{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:35:15Z","timestamp":1760243715877,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Radioactive iodide (131I\u2212) protection studies have focused primarily on the thyroid gland and disturbances in the hypothalamic-pituitary-thyroid axis. The objective of the current study was to establish 131I\u2212 urinary excretion profiles for saline, and the thyroid protectants, potassium iodide (KI) and ammonium perchlorate over a 75 hour time-course. Rats were administered 131I\u2212 and 3 hours later dosed with either saline, 30 mg\/kg of NH4ClO4 or 30 mg\/kg of KI. Urinalysis of the first 36 hours of the time-course revealed that NH4ClO4 treated animals excreted significantly more 131I\u2212 compared with KI and saline treatments. A second study followed the same protocol, but thyroxine (T4) was administered daily over a 3 day period. During the first 6\u201312 hour after 131I\u2212 dosing, rats administered NH4ClO4 excreted significantly more 131I\u2212 than the other treatment groups. T4 treatment resulted in increased retention of radioiodide in the thyroid gland 75 hour after 131I\u2212 administration. We speculate that the T4 treatment related reduction in serum TSH caused a decrease synthesis and secretion of thyroid hormones resulting in greater residual radioiodide in the thyroid gland. Our findings suggest that ammonium perchlorate treatment accelerates the elimination rate of radioiodide within the first 24 to 36 hours and thus may be more effective at reducing harmful exposure to 131I\u2212 compared to KI treatment for repeated dosing situations. Repeated dosing studies are needed to compare the effectiveness of these treatments to reduce the radioactive iodide burden of the thyroid gland.<\/jats:p>","DOI":"10.3390\/ijerph9082936","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T10:58:41Z","timestamp":1345114721000},"page":"2936-2948","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Radioactive Iodide (131I\u2212) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis"],"prefix":"10.3390","volume":"9","author":[{"given":"Curtis","family":"Harris","sequence":"first","affiliation":[{"name":"Institute for Health Management and Mass Destruction Defense, College of Public Health, University of Georgia, Athens, GA 30603, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cham","family":"Dallas","sequence":"additional","affiliation":[{"name":"Institute for Health Management and Mass Destruction Defense, College of Public Health, University of Georgia, Athens, GA 30603, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Rollor III","sequence":"additional","affiliation":[{"name":"Institute for Health Management and Mass Destruction Defense, College of Public Health, University of Georgia, Athens, GA 30603, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"White","sequence":"additional","affiliation":[{"name":"Institute for Health Management and Mass Destruction Defense, College of Public Health, University of Georgia, Athens, GA 30603, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Blount","sequence":"additional","affiliation":[{"name":"National Center for Environmental Health, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liza","family":"Valentin-Blasini","sequence":"additional","affiliation":[{"name":"National Center for Environmental Health, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Fisher","sequence":"additional","affiliation":[{"name":"National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,8,16]]},"reference":[{"key":"ref_1","unstructured":"(1977). 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