{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:18:54Z","timestamp":1791001134395,"version":"4.1.0"},"reference-count":168,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Drosophila melanogaster has been utilized to model human brain diseases. In most of these invertebrate transgenic models, some aspects of human disease are reproduced. Although investigation of rodent models has been of significant impact, invertebrate models offer a wide variety of experimental tools that can potentially address some of the outstanding questions underlying neurological disease. This review considers what has been gleaned from invertebrate models of neurodegenerative diseases, including Alzheimer\u2019s disease, Parkinson\u2019s disease, metabolic diseases such as Leigh disease, Niemann-Pick disease and ceroid lipofuscinoses, tumor syndromes such as neurofibromatosis and tuberous sclerosis, epilepsy as well as CNS injury. It is to be expected that genetic tools in Drosophila will reveal new pathways and interactions, which hopefully will result in molecular based therapy approaches.<\/jats:p>","DOI":"10.3390\/ijms10020407","type":"journal-article","created":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T14:24:15Z","timestamp":1233584655000},"page":"407-440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Drosophila melanogaster as a Model Organism of Brain Diseases"],"prefix":"10.3390","volume":"10","author":[{"given":"Astrid","family":"Jeibmann","sequence":"first","affiliation":[{"name":"Institute of Neuropathology, Domagkstra\u00dfe 19, 48149 M\u00fcnster, University Hospital M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Paulus","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Domagkstra\u00dfe 19, 48149 M\u00fcnster, University Hospital M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrg1554","article-title":"Research resources for Drosophila: The expanding universe","volume":"6","author":"Matthews","year":"2005","journal-title":"Nat Rev Genet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg1553","article-title":"Emerging technologies for gene manipulation in Drosophila melanogaster","volume":"6","author":"Venken","year":"2005","journal-title":"Nat Rev Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nature05954","article-title":"A genome-wide transgenic RNAi library for conditional gene inactivation in 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