{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:08:12Z","timestamp":1792534092296,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The native extracellular matrix (ECM) is composed of a cross-linked porous network of multifibril collagens and glycosaminoglycans. Nanofibrous scaffolds of silk fibroin (SF) and hydroxybutyl chitosan (HBC) blends were fabricated using 1,1,1,3,3,3-hexa\ufb02uoro-2-propanol (HFIP) and trifluoroacetic acid (TFA) as solvents to biomimic the native ECM via electrospinning. Scanning electronic microscope (SEM) showed that relatively uniform nanofibers could be obtained when 12% SF was blended with 6% HBC at the weight ratio of 50:50. Meanwhile, the average nano\ufb01brous diameter increased when the content of HBC in SF\/HBC blends was raised from 20% to 100%. Fourier transform infrared spectra (FTIR) and 13C nuclear magnetic resonance (NMR) showed SF and HBC molecules existed in hydrogen bonding interactions but HBC did not induce conformation of SF transforming from random coil form to \u03b2-sheet structure. X-ray diffraction (XRD) confirmed the different structure of SF\/HBC blended nanofibers from both SF and HBC. Thermogravimetry-Differential thermogravimetry (TG-DTG) results demonstrated that the thermal stability of SF\/HBC blend nanofibrous scaffolds was improved. The results indicated that the rearrangement of HBC and SF molecular chain formed a new structure due to stronger hydrogen bonding between SF and HBC. These electrospun SF\/HBC blended nanofibers may provide an ideal tissue engineering scaffold and wound dressing.<\/jats:p>","DOI":"10.3390\/ijms12042187","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T10:07:21Z","timestamp":1301911641000},"page":"2187-2199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Fabrication and Intermolecular Interactions of Silk Fibroin\/Hydroxybutyl Chitosan Blended Nanofibers"],"prefix":"10.3390","volume":"12","author":[{"given":"Kui-Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Zhen","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Mei","family":"Mo","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","article-title":"Tissue engineering","volume":"260","author":"Langer","year":"1993","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0142-9612(03)00593-3","article-title":"Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering","volume":"25","author":"Xu","year":"2004","journal-title":"Biomaterials"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.biomaterials.2003.08.045","article-title":"Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro","volume":"25","author":"Min","year":"2004","journal-title":"Biomaterials"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1021\/ma048988v","article-title":"Mechanical properties of electrospun silk fibers","volume":"37","author":"Wang","year":"2004","journal-title":"Macromolecules"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1097-4636(19990905)46:3<382::AID-JBM11>3.0.CO;2-R","article-title":"In vitro evaluation of the inflammatory potential of the silk fibroin","volume":"46","author":"Santin","year":"1999","journal-title":"J. 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