{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:36:55Z","timestamp":1760243815369,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T00:00:00Z","timestamp":1306454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Objective: To detect the expression and clinical significances of Lewis y antigen and integrin \u03b1v, \u03b23 in epithelial ovarian tumors, and to explore the expression correlation between Lewis y antigen and integrin \u03b1v, \u03b23. Methods: Immunohistochemical staining was performed in 95 cases of epithelial ovarian cancer, 37 cases of borderline tumors, 20 cases of benign tumors, and 20 cases of normal ovarian tissue, for the detection of Lewis y antigen and integrin \u03b1v, \u03b23 expressions, and to analyze the relationship between Lewis y antigen and integrin, and the relationship between clinical and pathological parameters of ovarian cancer. In addition, immunofluorescence double labeling was utilized to detect the expression correlation between Lewis y antigen and integrin \u03b1v, \u03b23 in ovarian cancer. Results: In epithelial ovarian tumors, the expression rate of Lewis y antigen was 81.05%, significantly higher than that of borderline (51.53%) (P &lt; 0.05) and benign (25%) (P &lt; 0.01) tumors, and normal ovarian tissues (0) (P &lt; 0.01). The expression rate of integrin \u03b1v, \u03b23 in malignant epithelial ovarian tumors was 78.95% and 82.11%, respectively, significantly higher than that of the borderline (45.94%, 40.54%) (both P &lt; 0.05), benign group (10.00%, 15.00%) (both P &lt; 0.01) and normal ovary group (5%, 15%) (both P &lt; 0.01). Conclusions: Lewis y and integrins \u03b1v, \u03b23 are relevant to pelvic and abdominal diffusion and metastasis of ovarian cancer cells, suggesting that these two molecules mediate a boosting function for tumor metastasis.<\/jats:p>","DOI":"10.3390\/ijms12063409","type":"journal-article","created":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T10:58:12Z","timestamp":1306493892000},"page":"3409-3421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Study on the Expression and Clinical Significances of Lewis y Antigen and Integrin \u03b1v, \u03b23 in Epithelial Ovarian Tumors"],"prefix":"10.3390","volume":"12","author":[{"given":"Yifei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China"},{"name":"Department of Obstetrics and Gynecology, the Second Affiliated Hospital of DalianMedical University, Dalian 116027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the Second Affiliated Hospital of DalianMedical University, Dalian 116027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanrong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuice","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Iwamori","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1073\/pnas.012540899","article-title":"The glycosynapse","volume":"99","author":"Senitiroh","year":"2002","journal-title":"Proc. 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