{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:20:17Z","timestamp":1779254417549,"version":"3.51.4"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T00:00:00Z","timestamp":1307664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>n this study, levels of plasma \u03b12-Heremans-Schmid glycoprotein, serum tumor necrosis factor-\u03b1, serum liver function parameters and short-term mortality were measured in 100 hepatitis B patients. Release of interleukin-6 and tumor necrosis factor-\u03b1 from the lipopolysaccharide-stimulated peripheral blood mononuclear cells in the presence\/absence of spermine and \u03b12-Heremans-Schmid glycoprotein were analyzed by enzyme-linked immunosorbent assay to determine the significance and potential mechanism of \u03b12-Heremans-Schmid glycoprotein in hepatitis B virus-associated liver damage. Results showed that serum \u03b12-Heremans-Schmid glycoprotein levels in acute-on-chronic liver failure patients were significantly lower than that in chronic hepatitis B patients or healthy controls (p &lt; 0.05). A negative dependence between serum human \u03b12-Heremans-Schmid glycoprotein and tumor necrosis factor-\u03b1 levels was observed. Interleukin-6 and tumor necrosis factor-\u03b1 levels in the lipopolysaccharide-induced peripheral blood mononuclear cell supernates were significantly reduced by spermine and\/or \u03b12-Heremans-Schmid glycoprotein. The latter two proteins jointly inhibited cytokine release. These observations suggest that plasma \u03b12-Heremans-Schmid glycoprotein is an independent marker of liver damage and a prognostic indicator of hepatitis B virus chronicity. It may reduce liver inflammation by partially inhibiting release of inflammatory factors from activated peripheral blood mononuclear cells.<\/jats:p>","DOI":"10.3390\/ijms12063846","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T12:35:40Z","timestamp":1307709340000},"page":"3846-3856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Protective Role of \u03b12HS-Glycoprotein in HBV-Associated Liver Failure"],"prefix":"10.3390","volume":"12","author":[{"given":"Xia-Hong","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Fang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-Sheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-Bing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Gong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF01239959","article-title":"A fetuin-related glycoprotein (alpha 2HS) in human embryonic and fetal development","volume":"248","author":"Dziegielewska","year":"1987","journal-title":"Cell Tissue Res"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/262226a0","article-title":"Origin of plasma alpha2HS-glycoprotein and its accumulation in bone","volume":"262","author":"Triffitt","year":"1976","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1432-1033.1997.00753.x","article-title":"Effect of phosphorylated rat fetuin on the growth of hepatocytes in primary culture in the presence of human hepatocyte-growth factor. 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