{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:32:36Z","timestamp":1785270756021,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T00:00:00Z","timestamp":1317859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Licorice has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. In this study, we evaluated the antihepatotoxic effect of licorice aqueous extract (LE) on the carbon tetrachloride (CCl4)-induced liver injury in a rat model. Hepatic damage, as reveled by histology and the increased activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, and decreased levels of serum total protein (TP), albumin (Alb) and globulin (G) were induced in rats by an administration of CCl4 at 3 mL\/kg b.w. (1:1 in groundnut oil). Licorice extract significantly inhibited the elevated AST, ALP and ALT activities and the decreased TP, Alb and G levels caused by CCl4 intoxication. It also enhanced liver super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), Glutathione S-transferase (GST) activities and glutathione (GSH) level, reduced malondialdehyde (MDA) level. Licorice extract still markedly reverses the increased liver hydroxyproline and serum TNF-\u03b1 levels induced by CCl4 intoxication. The data of this study support a chemopreventive potential of licorice extract against liver oxidative injury.<\/jats:p>","DOI":"10.3390\/ijms12106529","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T12:05:48Z","timestamp":1317902748000},"page":"6529-6543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl4-Induced Oxidative Damage in Rats"],"prefix":"10.3390","volume":"12","author":[{"given":"Hai Zhong","family":"Huo","sequence":"first","affiliation":[{"name":"Department of General Surgery, Ninth People\u2019s Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ninth People\u2019s Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Kang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ninth People\u2019s Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Yang","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ninth People\u2019s Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ninth People\u2019s Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,10,6]]},"reference":[{"key":"ref_1","first-page":"185","article-title":"Sinusoidal intercellular adhesion molecule-1 upregulation precedes the accumulation of leukocyte function antigen-1-positive cells and tissue necrosis in a model of carbon tetrachloride-induced acute rat liver injury","volume":"78","author":"Neubauer","year":"1998","journal-title":"Lab. 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