{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:02:34Z","timestamp":1791194554308,"version":"4.1.0"},"reference-count":92,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T00:00:00Z","timestamp":1323129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.<\/jats:p>","DOI":"10.3390\/ijms12128947","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T11:17:50Z","timestamp":1323170270000},"page":"8947-8960","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis"],"prefix":"10.3390","volume":"12","author":[{"given":"Mehlika","family":"Hazar-Rethinam","sequence":"first","affiliation":[{"name":"Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Endo-Munoz","sequence":"additional","affiliation":[{"name":"Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"Gannon","sequence":"additional","affiliation":[{"name":"Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Saunders","sequence":"additional","affiliation":[{"name":"Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia"},{"name":"School of Biomedical Sciences, University of Queensland, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1011-1344(97)00029-8","article-title":"Ultraviolet radiation and skin cancer of humans","volume":"40","author":"Urbach","year":"1997","journal-title":"J. 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