{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:16:37Z","timestamp":1791825397550,"version":"4.3.4"},"reference-count":118,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract anti-inflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products.<\/jats:p>","DOI":"10.3390\/ijms13033203","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T11:27:41Z","timestamp":1331206061000},"page":"3203-3228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["Tannins, Peptic Ulcers and Related Mechanisms"],"prefix":"10.3390","volume":"13","author":[{"given":"Neyres Zinia Taveira","family":"De Jesus","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heloina de Souza","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis Fernandes","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Jose de Almeida","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gedson Rodrigues de Morais","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Maria","family":"Barbosa-Filho","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josean Fechine","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Sobral da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr\u00f4nio Filgueiras de","family":"Athayde-Filho","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonia Maria","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-970, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"ref_1","unstructured":"Karama\u00e6, M Chelation of Cu(II), Zn(II), and Fe(II) by tannin constituents of selected edible nuts."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.3390\/ijms10125513","article-title":"Antioxidant activity of a red lentil extract and its fractions","volume":"10","author":"Amarowicz","year":"2009","journal-title":"Int. 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