{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:17:36Z","timestamp":1791112656969,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Methylmercury (MeHg) is a potent neurotoxin, and human beings are mainly exposed to this pollutant through fish consumption. We addressed the question of whether a diet mimicking the fish consumption of Wayanas Amerindians from French Guiana could result in observable adverse effects in mice. Wayanas adult men are subjected to a mean mercurial dose of 7 g Hg\/week\/kg of body weight. We decided to supplement a vegetarian-based mice diet with 0.1% of lyophilized Hoplias aimara fish, which Wayanas are fond of and equivalent to the same dose as that afflicting the Wayanas Amerindians. Total mercury contents were 1.4 \u00b1 0.2 and 5.4 \u00b1 0.5 ng Hg\/g of food pellets for the control and aimara diets, respectively. After 14 months of exposure, the body parts and tissues displaying the highest mercury concentration on a dry weight (dw) basis were hair (733 ng\/g) and kidney (511 ng\/g), followed by the liver (77 ng\/g). Surprisingly, despite the fact that MeHg is a neurotoxic compound, the brain accumulated low levels of mercury (35 ng\/g in the cortex). The metallothionein (MT) protein concentration only increased in those tissues (kidney, muscles) in which MeHg demethylation had occurred. This can be taken as a molecular sign of divalent mercurial contamination since only Hg2+ has been reported yet to induce MT accumulation in contaminated tissues. The suppression of the synthesis of the chemokine CCL2 in the corresponding knockout (KO) mice resulted in important changes in gene expression patterns in the liver and brain. After three months of exposure to an aimara-containing diet, eight of 10 genes selected (Sdhb, Cytb, Cox1, Sod1, Sod2, Mt2, Mdr1a and Bax) were repressed in wild-type mice liver whereas none presented a differential expression in KO Ccl2\u2212\/\u2212 mice. In the wild-type mice brain, six of 12 genes selected (Cytb, Cox1, Sod1, Sod2, Mdr1a and Bax) presented a stimulated expression, whereas all remained at the basal level of expression in KO Ccl2\u2212\/\u2212 mice. In the liver of aimara-fed mice, histological alterations were observed for an accumulated mercury concentration as low as 32 ng\/g, dw, and metal deposits were observed within the cytoplasm of hepatic cells.<\/jats:p>","DOI":"10.3390\/ijms13067710","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T18:56:28Z","timestamp":1340304988000},"page":"7710-7738","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Methylmercury Contained in a Diet Mimicking the Wayana Amerindians Contamination through Fish Consumption: Mercury Accumulation, Metallothionein Induction, Gene Expression Variations, and Role of the Chemokine CCL2"],"prefix":"10.3390","volume":"13","author":[{"given":"Jean-Paul","family":"Bourdineaud","sequence":"first","affiliation":[{"name":"Bordeaux University-CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Laclau","sequence":"additional","affiliation":[{"name":"Bordeaux University-CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gine","family":"Maury-Brachet","sequence":"additional","affiliation":[{"name":"Bordeaux University-CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Bordeaux University-CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Baudrimont","sequence":"additional","affiliation":[{"name":"Bordeaux University-CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Mesmer-Dudons","sequence":"additional","affiliation":[{"name":"Bordeaux University-CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatake","family":"Fujimura","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease, Pathology Section, Department of Basic Medical Sciences, 4058-18 Hama, Minamata, Kumamoto 867-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Marighetto","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurosciences Cognitives, Bordeaux University-CNRS UMR 5106, Avenue des Facult\u00e9s, Talence, 33405, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Godefroy","sequence":"additional","affiliation":[{"name":"Institut de la Vision, UMRS 968, INSERM-University Pierre et Marie Curie, 17 Rue Moreau, Paris, 75012, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Rost\u00e8ne","sequence":"additional","affiliation":[{"name":"Institut de la Vision, UMRS 968, INSERM-University Pierre et Marie Curie, 17 Rue Moreau, Paris, 75012, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Br\u00e8thes","sequence":"additional","affiliation":[{"name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, UMR 5095 CNRS-Bordeaux University, 1 rue Camille Saint-Sa\u00ebns, Bordeaux, 33077 Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ntt.2006.02.004","article-title":"Impact of prenatal methylmercury toxicity on neurobehavioral function at age 14 years","volume":"28","author":"Debes","year":"2006","journal-title":"Neurotoxicol. Teratol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuro.2009.01.005","article-title":"Postnatal exposure to methyl mercury from fish consumption: A review and new data from the Seychelles Child Development Study","volume":"30","author":"Myers","year":"2009","journal-title":"Neurotoxicology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/enrs.2002.4349","article-title":"Neurodevelopmental investigations among methylmercury-exposed children in French Guiana","volume":"89","author":"Cordier","year":"2002","journal-title":"Environ. Res"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuro.2008.09.012","article-title":"Qualitative assessment of visuospatial errors in mercury-exposed Amazonian children","volume":"30","author":"Chevrier","year":"2009","journal-title":"Neurotoxicology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/enrs.2002.4389","article-title":"Mercury exposure in Munduruku Indians from the community of Sai Cinza, State of Par\u00e1, Brazil","volume":"90","author":"Santos","year":"2002","journal-title":"Environ. Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/enrs.2000.4088","article-title":"Mercury exposures in riverside Amazon communities in Par\u00e1, Brazil","volume":"84","author":"Santos","year":"2000","journal-title":"Environ. Res"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s004200050027","article-title":"Methylmercury exposure affects motor performance of a riverine population of the Tapaj\u00f3s river, Brazilian Amazon","volume":"73","author":"Dolbec","year":"2000","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1289\/ehp.99107587","article-title":"Methylmercury neurotoxicity in Amazonian children downstream from gold mining","volume":"107","author":"Grandjean","year":"1999","journal-title":"Environ. Health Perspect"},{"key":"ref_9","first-page":"157","article-title":"Evidence of early nervous system dysfunction in Amazonian populations exposed to low levels of methylmercury","volume":"17","author":"Lebel","year":"1996","journal-title":"Neurotoxicology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/enrs.1998.3846","article-title":"Neurotoxic effects of low-level methylmercury contamination in the Amazonian Basin","volume":"79","author":"Lebel","year":"1998","journal-title":"Environ. Res"},{"key":"ref_11","first-page":"449","article-title":"Gold-mining activities and mercury contamination of native amerindian communities in French Guiana: Key role of fish in dietary uptake","volume":"109","author":"Maillot","year":"2001","journal-title":"Environ. Health Perspect"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bourdineaud, J.P., Bellance, N., B\u00e9nard, G., Br\u00e8thes, D., Fujimura, M., Gonzalez, P., Marighetto, A., Maury-Brachet, R., Morm\u00e8de, C., and P\u00e9dron, V. (2008). Feeding mice with diets containing mercury-contaminated fish flesh from French Guiana: A model for the mercurial intoxication of the Wayana Amerindians. Environ. Health, 7.","DOI":"10.1186\/1476-069X-7-53"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1590\/S0100-879X2007000300001","article-title":"Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity","volume":"40","author":"Aschner","year":"2007","journal-title":"Braz. J. Med. Biol. Res"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.it.2005.08.001","article-title":"Chemokines, chemokine receptors and pain","volume":"26","author":"Abbadie","year":"2005","journal-title":"Trends Immunol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nrn2255","article-title":"Chemokines: A new class of neuromodulator?","volume":"8","author":"Rostene","year":"2007","journal-title":"Nat. Rev. Neurosci"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/toxsci\/kfr252","article-title":"Protection by the chemokine CCL2 of the neurotoxic effect of methylmercury","volume":"125","author":"Godefroy","year":"2012","journal-title":"Toxicol. Sci"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1021\/es049149r","article-title":"Synergic effect of gold mining and damming on mercury contamination in fish","volume":"39","author":"Boudou","year":"2005","journal-title":"Environ. Sci. Technol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ecoenv.2004.05.004","article-title":"Goldmining and mercury contamination of the piscivorous fish Hoplias aimara in French Guiana (Amazon basin)","volume":"60","author":"Durrieu","year":"2005","journal-title":"Ecotoxicol. Environ. Saf"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.187.4.601","article-title":"Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice","volume":"187","author":"Lu","year":"1998","journal-title":"J. Exp. Med"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1139\/f89-147","article-title":"Determination of picogram levels of methylmercury by aqueous phase ethylation, followed by cryogenic gas chromatography with cold vapor atomic fluorescence detection","volume":"46","author":"Bloom","year":"1989","journal-title":"Can. J. Fish Aquat. Sci"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.aquatox.2005.05.015","article-title":"Impact of cadmium contamination and oxygenation levels on biochemical responses in the Asiatic clam Corbicula fluminea","volume":"74","author":"Legeay","year":"2005","journal-title":"Aquat. Toxicol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.envint.2010.09.003","article-title":"Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations\u2019 average fish consumption","volume":"37","author":"Bourdineaud","year":"2011","journal-title":"Environ. Int"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/33.3.2579122","article-title":"Silver amplification of mercury sulfide and selenide: A histochemical method for light and electron microscopic localization of mercury in tissue","volume":"33","author":"Danscher","year":"1985","journal-title":"J. Histochem. Cytochem"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0040-8166(96)80058-9","article-title":"Tissue and cell distribution of copper, zinc and cadmium in the mussel, Mytilus galloprovincialis, determined by autometallography","volume":"28","author":"Soto","year":"1996","journal-title":"Tissue Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.fct.2004.03.013","article-title":"Higher fecal excretion and lower tissue accumulation of mercury in Wistar rats from contaminated fish than from methylmercury chloride added to fish","volume":"42","author":"Berntssen","year":"2004","journal-title":"Food Chem. Toxicol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.immuni.2009.09.010","article-title":"Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology","volume":"31","author":"Ransohoff","year":"2009","journal-title":"Immunity"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jhep.2006.09.007","article-title":"Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice","volume":"46","author":"Zamara","year":"2007","journal-title":"J. Hepatol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2174\/187152809789352230","article-title":"Monocytes and macrophages as cellular targets in liver fibrosis","volume":"8","author":"Heymann","year":"2009","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.22952","article-title":"CCR2 promotes hepatic fibrosis in mice","volume":"50","author":"Seki","year":"2009","journal-title":"Hepatology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ijc.24800","article-title":"Monocyte chemoattractant protein-1 (MCP-1)\/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells","volume":"126","author":"Dagouassat","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"916","DOI":"10.2337\/db09-1403","article-title":"CCR2 regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis","volume":"59","author":"Obstfeld","year":"2010","journal-title":"Diabetes"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5551\/jat.3368","article-title":"C\u2013C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice","volume":"17","author":"Tamura","year":"2010","journal-title":"J. Atheroscler. Thromb"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1074\/jbc.M707886200","article-title":"Homocysteine induces monocyte chemoattractant protein-1 expression in hepatocytes mediated via activator protein-1 activation","volume":"283","author":"Woo","year":"2008","journal-title":"J. Biol. Chem"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jech.40.2.181","article-title":"Methylmercury exposure and mortality in southern Japan: A close look at causes of death","volume":"40","author":"Tamashiro","year":"1986","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0015-6264(73)80495-X","article-title":"A histochemical study on some enzyme changes in the kidney, liver and brain after chronic mercury intoxication in the rat","volume":"11","author":"Chang","year":"1973","journal-title":"Food Cosmet. Toxicol"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0013-9351(75)90074-2","article-title":"Ultrastructural changes in the liver after chronic exposure to methylmercury","volume":"10","author":"Desnoyers","year":"1975","journal-title":"Environ. Res"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0013-9351(74)90144-3","article-title":"Ultrastructural changes in the liver after long-term diet of mercury-contaminated tuna","volume":"7","author":"Chang","year":"1974","journal-title":"Environ. Res"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ecoenv.2010.10.012","article-title":"Evaluation of protective effects of fish oil against oxidative damage in rats exposed to methylmercury","volume":"74","author":"Grotto","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-0773.1993.tb01563.x","article-title":"Effects of dietary alpha-tocopherol and beta-carotene on lipid peroxidation induced by methyl mercuric chloride in mice","volume":"73","author":"Andersen","year":"1993","journal-title":"Pharmacol. Toxicol"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainresbull.2008.11.001","article-title":"Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice","volume":"79","author":"Funck","year":"2009","journal-title":"Brain Res. Bull"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s10534-010-9367-4","article-title":"In vivo and in vitro inhibition of mice thioredoxin reductase by methylmercury","volume":"23","author":"Wagner","year":"2010","journal-title":"Biometals"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00204-011-0652-y","article-title":"Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats","volume":"85","author":"Barcelos","year":"2011","journal-title":"Arch. Toxicol"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00204-007-0209-2","article-title":"Comparative study of activities in reactive oxygen species production\/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity","volume":"81","author":"Mori","year":"2007","journal-title":"Arch. Toxicol"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.fct.2008.01.015","article-title":"Dietary fats modulate methylmercury-mediated systemic oxidative stress and oxidative DNA damage in rats","volume":"46","author":"Jin","year":"2008","journal-title":"Food Chem. Toxicol"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1091581809337918","article-title":"Effects of mixtures of polychlorinated biphenyls, methylmercury, and organochlorine pesticides on hepatic DNA methylation in prepubertal female Sprague-Dawley rats","volume":"28","author":"Desaulniers","year":"2009","journal-title":"Int. J. Toxicol"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3200\/AEOH.61.5.232-238","article-title":"New evidence on the effects of tea on mercury metabolism in humans","volume":"61","author":"Canuel","year":"2006","journal-title":"Arch. Environ. Occup. Health"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.fct.2008.12.020","article-title":"Synergistic neurotoxicity induced by methylmercury and quercetin in mice","volume":"47","author":"Dalmarco","year":"2009","journal-title":"Food Chem. Toxicol"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ntt.2009.08.007","article-title":"Neurobehavioral effect of chronic and bolus doses of methylmercury following prenatal exposure in C57BL\/6 weanling mice","volume":"31","author":"Liang","year":"2009","journal-title":"Neurotoxicol. Teratol"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00204-007-0254-x","article-title":"Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice","volume":"82","author":"Sugawara","year":"2008","journal-title":"Arch. Toxicol"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1289\/ehp.10906","article-title":"Emergence of delayed methylmercury toxicity after perinatal exposure in metallothionein-null and wild-type C57BL mice","volume":"116","author":"Yoshida","year":"2008","journal-title":"Environ. Health Perspect"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1471-4159.2008.05484.x","article-title":"Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury","volume":"106","author":"Onishchenko","year":"2008","journal-title":"J. Neurochem"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxlet.2007.11.004","article-title":"Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: Oxidative stress and down-regulated Na+\/K+-ATPase involved","volume":"176","author":"Huang","year":"2008","journal-title":"Toxicol. Lett"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2008.03.008","article-title":"Chronic, low-dose prenatal exposure to methylmercury impairs motor and mnemonic function in adult C57\/B6 mice","volume":"191","author":"Montgomery","year":"2008","journal-title":"Behav. Brain Res"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bj\u00f6rkman, L., Lundekvam, B.F., Laegreid, T., Bertelsen, B.I., Morild, I., Lilleng, P., Lind, B., Palm, B., and Vahter, M (2007). Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study. Environ. Health, 6.","DOI":"10.1186\/1476-069X-6-30"},{"key":"ref_55","first-page":"867","article-title":"Cadmium, mercury, and lead in kidney cortex of the general Swedish population: A study of biopsies from living kidney donors","volume":"107","author":"Svalander","year":"1999","journal-title":"Environ. Health Perspect"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/13\/6\/7710\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:50:55Z","timestamp":1760219455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/13\/6\/7710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,21]]},"references-count":55,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6]]}},"alternative-id":["ijms13067710"],"URL":"https:\/\/doi.org\/10.3390\/ijms13067710","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,21]]}}}