{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T23:57:47Z","timestamp":1771718267739,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ovarian cancer is the most lethal gynecologic malignancy. Despite advances in chemotherapy, the five-year survival rate of advanced ovarian cancer patients with peritoneal metastasis remains around 30%. The most significant prognostic factor is stage, and most patients present at an advanced stage with peritoneal dissemination. There is often no clearly identifiable precursor lesion; therefore, the events leading to metastatic disease are poorly understood. This article reviews metastatic suppressor genes, the epithelial-mesenchymal transition (EMT), and the tumor microenvironment as they relate to ovarian cancer metastasis. Additionally, novel chemotherapeutic agents targeting the metastasis-related biochemical pathways are discussed.<\/jats:p>","DOI":"10.3390\/ijms130911705","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T11:13:20Z","timestamp":1347966800000},"page":"11705-11717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways"],"prefix":"10.3390","volume":"13","author":[{"given":"Kentaro","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.semcancer.2010.12.005","article-title":"Metastasis suppressors and the tumor microenvironment","volume":"21","author":"Cook","year":"2011","journal-title":"Semin. 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