{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:46:29Z","timestamp":1787028389402,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T00:00:00Z","timestamp":1353628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Objective: To measure Lewis y and integrin \u03b15\u03b21 expression in epithelial ovarian carcinoma and to correlate the levels of these molecules with ovarian carcinoma chemotherapy and prognosis. Methods: The study population included 34 ovarian carcinoma patients with chemotherapeutic drug-resistance, six partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). Immunochemistry was used to determine expression of Lewis y antigen and integrin \u03b15\u03b21 in ovarian carcinoma tissues, and correlation of these molecules with chemotherapy resistance was further investigated, Multi-factor logistic regression analysis was applied to investigate: age, surgical stage, grade, subtype of patient cases, metastasis of lymph nodes, residual tumor size, expression levels of Lewis y antigen and integrin \u03b15\u03b21 correlation with ovarian carcinoma chemotherapy resistance. Results: The expression rates of Lewis y antigen and integrins \u03b15 and \u03b21 were significantly greater in the drug-resistant group (91.17%, 85.29%, 88.24%) than the partially sensitive (50.00%, 33.33%, 50.00%) or sensitive groups (61.54%, 57.69%, 55.77%). Binary logistic regression analysis revealed that surgical stage, residual tumor size, and expression of integrin \u03b15 and Lewis y in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance. Conclusions: Overexpression of Lewis y and integrin \u03b15 are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.<\/jats:p>","DOI":"10.3390\/ijms131215588","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T11:11:54Z","timestamp":1353669114000},"page":"15588-15600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Elevated Levels of Lewis Y and Integrin \u03b15\u03b21 Correlate with Chemotherapeutic Drug Resistance in Epithelial Ovarian Carcinoma"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhenhua","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0889-8545(21)00312-0","article-title":"Primary chemotherapy in epithelial ovarian cancer","volume":"4","author":"Hurwitz","year":"1994","journal-title":"Obstet. 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