{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:54:57Z","timestamp":1790402097419,"version":"4.1.0"},"reference-count":160,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which represent a major health problem, particularly in impecunious areas. Unlike most antibiotics, there is no \u201cgeneral\u201d antiparasitic drug available. Here, the selection of antiparasitic drugs varies between different organisms. Some of the currently available drugs are chemically de novo synthesized, however, the majority of drugs are derived from natural sources such as plants which have subsequently been chemically modified to warrant higher potency against these human pathogens. In this review article we will provide an overview of the current  status of plant derived pharmaceuticals and their chemical modifications to target  parasite-specific peculiarities in order to interfere with their proliferation in the  human host.<\/jats:p>","DOI":"10.3390\/ijms14023395","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T11:02:06Z","timestamp":1360148526000},"page":"3395-3439","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Natural Products as a Source for Treating Neglected  Parasitic Diseases"],"prefix":"10.3390","volume":"14","author":[{"given":"Dieudonn\u00e9","family":"Ndjonka","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaoundere, B. P. 454, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Rapado","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes 1374, 05508-000 S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4528-4732","authenticated-orcid":false,"given":"Ariel","family":"Silber","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes 1374, 05508-000 S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Liebau","sequence":"additional","affiliation":[{"name":"Institute for Zoophysiology, Schlossplatz 8, D-48143 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Wrenger","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes 1374, 05508-000 S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.2174\/092986712800229087","article-title":"The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases\u2014Part II","volume":"19","author":"Schmidt","year":"2012","journal-title":"Curr. Med. Chem"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.2174\/092986712800229023","article-title":"The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases\u2014Part I","volume":"19","author":"Schmidt","year":"2012","journal-title":"Curr. Med. 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