{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:08:17Z","timestamp":1787962097172,"version":"build-2784847793"},"reference-count":68,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the control of the suprachiasmatic nucleus (SCN) and the light\/dark cycle. This indole plays an important role in many physiological processes including circadian entrainment, blood pressure regulation, seasonal reproduction, ovarian physiology, immune function, etc. Recently, the investigation and applications of melatonin in the hard tissues bone and tooth have received great attention. Melatonin has been investigated relative to bone remolding, osteoporosis, osseointegration of dental implants and dentine formation. In the present review, we discuss the large body of published evidence and review data of melatonin effects on hard tissues, specifically, bone and tooth.<\/jats:p>","DOI":"10.3390\/ijms140510063","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T14:17:28Z","timestamp":1368195448000},"page":"10063-10074","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Melatonin Effects on Hard Tissues: Bone and Tooth"],"prefix":"10.3390","volume":"14","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University,  Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University,  Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Wen","family":"He","sequence":"additional","affiliation":[{"name":"Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University,  Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"key":"ref_1","first-page":"19","article-title":"Melatonin in humans","volume":"57","author":"Karasek","year":"2006","journal-title":"J. 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