{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:10:57Z","timestamp":1790262657622,"version":"4.1.0"},"reference-count":174,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of  melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.<\/jats:p>","DOI":"10.3390\/ijms14058924","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T10:35:11Z","timestamp":1366886111000},"page":"8924-8947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Melatonin-Based Therapeutics for Neuroprotection in Stroke"],"prefix":"10.3390","volume":"14","author":[{"given":"Kazutaka","family":"Shinozuka","sequence":"first","affiliation":[{"name":"Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa,  FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan","family":"Staples","sequence":"additional","affiliation":[{"name":"Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa,  FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Borlongan","sequence":"additional","affiliation":[{"name":"Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa,  FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"ref_1","first-page":"456","article-title":"Pineal Cross-Transplantation (Old-to-Young and Vice Versa) as Evidence for an Endogenous Aging Clock","volume":"719","author":"Pierpaoli","year":"1994","journal-title":"The Aging Clock: The Pineal Gland and Other Pacemakers in the Progression of Aging and Carcinogenesis: Third Stromboli Conference on Aging and Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF01400646","article-title":"Behavioral assessment of pinealectomy and fetal pineal-gland transplantation in rats: Part II","volume":"128","author":"Palaoglu","year":"1994","journal-title":"Acta Neurochir"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.91.2.787","article-title":"Pineal control of aging: Effect of melatonin and pineal grafting on aging mice","volume":"91","author":"Pierpaoli","year":"1994","journal-title":"Proc. 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