{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:19:48Z","timestamp":1790572788103,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oxidative stress has been implicated as an important contributing factor in the pathogenesis of several pulmonary inflammatory diseases. Previous studies have indicated a relationship between oxidative stress and the attenuation of epithelial tight junctions (TJs). In Human Bronchial Epithelial-16 cells (16HBE), we demonstrated the degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase C\u03b31 (PLC\u03b31) and the protein kinase C\u03b1 (PKC\u03b1) signaling cascade.<\/jats:p>","DOI":"10.3390\/ijms14059475","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T11:20:49Z","timestamp":1367234449000},"page":"9475-9486","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Oxidative Stress Mediates the Disruption of Airway  Epithelial Tight Junctions through a TRPM2-PLC\u03b31-PKC\u03b1 Signaling Pathway"],"prefix":"10.3390","volume":"14","author":[{"given":"Rui","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, the Second Affiliated Hospital,  Chongqing University of Medical Science, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, the Second Affiliated Hospital,  Chongqing University of Medical Science, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, the Second Affiliated Hospital,  Chongqing University of Medical Science, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliy","family":"Perelman","sequence":"additional","affiliation":[{"name":"Far Eastern Scientific Center of Physiology and Pathology of Respiration,  Russian Academy of Medical Sciences, Blagoveschensk 675000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Kolosov","sequence":"additional","affiliation":[{"name":"Far Eastern Scientific Center of Physiology and Pathology of Respiration,  Russian Academy of Medical Sciences, Blagoveschensk 675000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0006-291X(02)03029-2","article-title":"The effect of oxidative stress on histone acetylation and IL-8 release","volume":"301","author":"Tomita","year":"2003","journal-title":"Biochem. 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