{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:42:30Z","timestamp":1761561750061,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Helicobacter pylori (H. pylori) infection is the main cause of gastritis,  gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized.<\/jats:p>","DOI":"10.3390\/ijms14059487","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T11:20:49Z","timestamp":1367234449000},"page":"9487-9496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of microRNA in Gastric Malignancy"],"prefix":"10.3390","volume":"14","author":[{"given":"Toshihiro","family":"Nishizawa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine,  Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan"},{"name":"Division of Gastroenterology, National Hospital Organization Tokyo Medical Center,  2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine,  Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10120-009-0507-x","article-title":"Helicobacter pylori and gastric cancer","volume":"12","author":"Suzuki","year":"2009","journal-title":"Gastric Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2217\/fmb.10.25","article-title":"Helicobacter pylori eradication therapy","volume":"5","author":"Suzuki","year":"2010","journal-title":"Future Microbiol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000209219","article-title":"Early Helicobacter pylori eradication restores sonic hedgehog expression in the gastric mucosa of Mongolian gerbils","volume":"79","author":"Nishizawa","year":"2009","journal-title":"Digestion"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0140-6736(08)61159-9","article-title":"Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: An open-label, randomised controlled trial","volume":"372","author":"Fukase","year":"2008","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00535-008-2285-3","article-title":"The role of microRNAs in gastrointestinal cancers","volume":"44","author":"Saito","year":"2009","journal-title":"J. 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