{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:29:39Z","timestamp":1787239779506,"version":"build-2736575974"},"reference-count":150,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T00:00:00Z","timestamp":1377216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Latent Epstein-Barr virus (EBV) infection is an etiological factor in the progression of several human epithelial malignancies such as nasopharyngeal carcinoma (NPC) and a subset of gastric carcinoma. Reports have shown that EBV produces several viral oncoproteins, yet their pathological roles in carcinogenesis are not fully elucidated. Studies on the recently discovered of EBV-encoded microRNAs (ebv-miRNAs) showed that these small molecules function as post-transcriptional gene regulators and may play a role in the carcinogenesis process. In NPC and EBV positive gastric carcinoma (EBVaGC), 22 viral miRNAs which are located in the long alternative splicing EBV transcripts, named BamH1 A rightward transcripts (BARTs), are abundantly expressed. The importance of several miR-BARTs in carcinogenesis has recently been demonstrated. These novel findings enhance our understanding of the oncogenic properties of EBV and may lead to a more effective design of therapeutic regimens to combat EBV-associated malignancies. This article will review the pathological roles of miR-BARTs in modulating the expression of cancer-related genes in both host and viral genomes. The expression of other small  non-coding RNAs in NPC and the expression pattern of miR-BARTs in rare  EBV-associated epithelial cancers will also be discussed.<\/jats:p>","DOI":"10.3390\/ijms140917378","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T11:38:05Z","timestamp":1377257885000},"page":"17378-17409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Emerging Roles of Small Epstein-Barr Virus Derived  Non-Coding RNAs in Epithelial Malignancy"],"prefix":"10.3390","volume":"14","author":[{"given":"Raymond","family":"Lung","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Fai","family":"To","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Institute of Digestive Diseases, Li Ka-Shing Institute of Health Sciences,  The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"ref_1","first-page":"1233","article-title":"A second virus-carrying tissue culture strain (Eb2) of lymphoblasts from burkitt\u2019s lymphoma","volume":"12","author":"Epstein","year":"1964","journal-title":"Pathol. 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