{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:42:30Z","timestamp":1789872150036,"version":"4.0.1"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The present study investigates cytogenetic damage in lymphocytes, derived from three victims who were unfortunately exposed to cobalt-60 (60Co) radiation (the 1999 accident occurred in a village in China\u2019s Henan province). Case A of the three victims was exposed to a higher dose of 60Co radiation than Cases B and C. The chromosomal aberrations, cytokinesis-block micronucleus (CBMN, the CBMN assay), and DNA  double-strand breaks (DSBs, the comet assay) examined in this study are biomarkers for cytogenetic abnormalities. After the lymphocytes collected from the victims were cultured, the frequencies of dicentric chromosomes and rings (dic + r) and CBMN in the first mitotic division detected in the lymphocytes of Case A were found to be substantially higher than in Cases B and C. Similarly, the DNA-DSB level found in the peripheral blood collected from Case A was much higher than those of Cases B and C. These results suggest that an acutely enhanced induction of the 60Co-induced cytogenetic abnormality frequency in humans depends on the dose of 60Co radiation. This finding is supported by the data obtained using practical techniques to evaluate early lymphoid-tissue abnormalities induced after exposure to acute radiation.<\/jats:p>","DOI":"10.3390\/ijms140917525","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T03:10:49Z","timestamp":1377659449000},"page":"17525-17535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cytogenetic Abnormalities in Lymphocytes from Victims Exposed to Cobalt-60 Radiation"],"prefix":"10.3390","volume":"14","author":[{"given":"Jia","family":"Cao","sequence":"first","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Third Central Hospital, Tianjin 300170, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"National Institute for Radiological Protection and Nuclear Safety, Chinese Centre for Disease Control, Beijing 100088, China"},{"name":"Medical Emergency Response Centre for Nuclear Accident, Ministry of Health,  Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Su","sequence":"additional","affiliation":[{"name":"National Institute for Radiological Protection and Nuclear Safety, Chinese Centre for Disease Control, Beijing 100088, China"},{"name":"Medical Emergency Response Centre for Nuclear Accident, Ministry of Health,  Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"},{"name":"Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China"},{"name":"First Clinical Department of Medical Emergency Response Centre for Nuclear Accident,  Ministry of Health, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1148\/radiol.09090330","article-title":"Medical response to a major radiologic emergency: A primer for medical and public health 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