{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:07:50Z","timestamp":1791173270371,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>3,3',4,4',5,5'-Hexahydroxy-trans-stilbene (M8) is a synthetic resveratrol derivative, advertised as a candidate drug highly effective against numerous malignancies. Because multiple tumors prone to M8 frequently metastasize into the peritoneal cavity, this study was aimed at establishing the effect of M8 on the growth and senescence of human peritoneal mesothelial cells (HPMCs), the largest cell population within the peritoneum, actively involved in the intraperitoneal spread of cancer. The study showed that M8, used at the highest non-toxic dose of 10 \u03bcM, impairs proliferation and accelerates senescence  in cultured HPMCs via an oxidative stress-dependent mechanism. At the same time,  soluble factors released to the environment by HPMCs that senesced prematurely  in response to M8 promoted growth of colorectal and pancreatic carcinomas in vitro.  These findings indicate that M8 may indirectly\u2014through the modification of normal (mesothelial) cells phenotype\u2014facilitate an expansion of cancer cells, which challenges the postulated value of this stilbene in chemotherapy.<\/jats:p>","DOI":"10.3390\/ijms141122483","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T11:24:25Z","timestamp":1384428265000},"page":"22483-22498","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Synthetic Resveratrol Analogue,  3,3',4,4',5,5'-Hexahydroxy-trans-Stilbene, Accelerates Senescence in Peritoneal Mesothelium and Promotes Senescence-Dependent Growth of Gastrointestinal Cancers"],"prefix":"10.3390","volume":"14","author":[{"given":"Justyna","family":"Miku\u0142a-Pietrasik","sequence":"first","affiliation":[{"name":"Laboratory of Gerontology, Department of Pathophysiology,  Pozna\u0144 University of Medical Sciences, \u015awi\u0119cickiego 6 Str., Pozna\u0144 60-781, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Sosi\u0144ska","sequence":"additional","affiliation":[{"name":"Laboratory of Gerontology, Department of Pathophysiology,  Pozna\u0144 University of Medical Sciences, \u015awi\u0119cickiego 6 Str., Pozna\u0144 60-781, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Wierzchowski","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology of Drugs, Pozna\u0144 University of Medical Sciences, Grunwaldzka 6, Pozna\u0144 60-780, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Piwocka","sequence":"additional","affiliation":[{"name":"Laboratory of Cytometry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, Warsaw 02-093, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Ksi\u0105\u017cek","sequence":"additional","affiliation":[{"name":"Laboratory of Gerontology, Department of Pathophysiology,  Pozna\u0144 University of Medical Sciences, \u015awi\u0119cickiego 6 Str., Pozna\u0144 60-781, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature02789","article-title":"Sirtuin activators mimic caloric restriction and delay ageing in metazoans","volume":"430","author":"Wood","year":"2004","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/gerona\/glq161","article-title":"Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts","volume":"66","author":"Giovannelli","year":"2011","journal-title":"J. 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