{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:10:25Z","timestamp":1784902225875,"version":"3.55.0"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Eighteen N-substituted phenyl-2-acyloxycyclohexylsulfonamides (III)  were designed and synthesized by the reaction of N-substituted phenyl-2-hydroxyl- cycloalkylsulfonamides (I, R1) with acyl chloride (II, R2) in dichloromethane under the catalysis of TMEDA and molecular sieve. High fungicidal active compound N-(2,4,5-trichlorophenyl)-2-(2-ethoxyacetoxy) cyclohexylsulfonamide (III-18) was screened out. Mycelia growth assay against the Botrytis cinerea exhibited that EC50 and EC80 of compound III-18 were 4.17 and 17.15 \u03bcg mL\u22121 respectively, which was better than the commercial fungicide procymidone (EC50 = 4.46 \u03bcg mL\u22121 and EC80 = 35.02 \u03bcg mL\u22121). For in vivo activity against B. cinerea in living leaf of cucumber, the control effect of compound III-18 was better than the fungicide cyprodinil. In addition, this new compound had broader fungicidal spectra than chlorothalonil.<\/jats:p>","DOI":"10.3390\/ijms141122544","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T11:24:25Z","timestamp":1384428265000},"page":"22544-22557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Synthesis of 2-Acyloxycyclohexylsulfonamides and Evaluation on Their Fungicidal Activity"],"prefix":"10.3390","volume":"14","author":[{"given":"Xinghai","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zining","family":"Cui","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control,  Department of Plant Pathology, College of Natural Resources and Environment,  South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0223-5234(99)00215-9","article-title":"New 2-sulfonamidothiazoles substituted at C-4: Synthesis of polyoxygenated aryl derivatives and in vitro evaluation of antifungal activity","volume":"34","author":"Pierre","year":"1999","journal-title":"Eur. 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