{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:52:26Z","timestamp":1791831146762,"version":"4.3.4"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["IJMS"],"abstract":"<jats:p>A simple protocol, involving the green synthesis for the construction of novel  bis-pyrimidine derivatives, 3a\u2013i and 4a\u2013e are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%\u201399%).<\/jats:p>","DOI":"10.3390\/ijms141223762","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T11:35:30Z","timestamp":1386243330000},"page":"23762-23773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to  Bis-Pyrimidine Derivatives"],"prefix":"10.3390","volume":"14","author":[{"given":"Abdullah","family":"Al-Majid","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455,  Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-3201","authenticated-orcid":false,"given":"Assem","family":"Barakat","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455,  Riyadh 11451, Saudi Arabia"},{"name":"Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426-Ibrahimia, Alexandria 21321, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"AL-Najjar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, King Saud University, P.O. 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