{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:46:16Z","timestamp":1790682376221,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:00:00Z","timestamp":1386547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>miR-155 plays a crucial role in proinflammatory activation. This study was carried out to assess the association of abnormal expression of miR-155 in peripheral blood of patients with Rheumatoid arthritis with the expression of TNF-\u03b1 and IL-1\u03b2. Release of TNF-\u03b1 and IL-1\u03b2, and expression of miR-155 were determined in RA peripheral blood or peripheral blood macrophages, followed by correlation analysis of the cytokines release and miR-155 expression. Furthermore, in vitro studies indicate that miR-155 inhibited the expression of SOCS1. Our results suggest that there is a correlation between the high-level expression of miR-155 and the enhanced expression of TNF-\u03b1 and IL-1\u03b2. miR-155 targets and suppresses the expression of SOCS1, and the decrease of SOCS1 may lead to the upregulation of TNF-\u03b1 and IL-1\u03b2.<\/jats:p>","DOI":"10.3390\/ijms141223910","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T12:47:59Z","timestamp":1386593279000},"page":"23910-23921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["RETRACTED: Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-\u03b1 and IL-1\u03b2 in PBMCs"],"prefix":"10.3390","volume":"14","author":[{"given":"Xiaochuan","family":"Li","sequence":"first","affiliation":[{"name":"The Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University,  36 Sanhao Street, Heping District, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"The Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University,  36 Sanhao Street, Heping District, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University,  36 Sanhao Street, Heping District, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.7326\/0003-4819-136-12-200206180-00012","article-title":"Rheumatoid arthritis\u2014A molecular understanding","volume":"136","author":"Smith","year":"2002","journal-title":"Ann. 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