{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:58:39Z","timestamp":1778299119121,"version":"3.51.4"},"reference-count":111,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A hypothesis, based primarily on the occurrence of multiple sclerosis (MS) in the Faroe  Islands and supported by numerous analytical epidemiological studies, is described. It proposes that MS is caused by the interaction of a virus disease with  intestinal pathology, e.g., infectious mononucleosis, and application of smoked and  nitrate\/nitrite-cured meat products in the diet during circumscribed time intervals. The biological mechanisms might involve a break of tolerance by an alteration of self within the central nervous system, by nitrophenylated compounds conjugated to animal tissue, in particular to proteins occurring in the central nervous system. Further research is needed.<\/jats:p>","DOI":"10.3390\/ijms15033533","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T11:03:00Z","timestamp":1393412580000},"page":"3533-3545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Notes on the Epidemiology of Multiple Sclerosis,  with Special Reference to Dietary Habits"],"prefix":"10.3390","volume":"15","author":[{"given":"Klaus","family":"Lauer","sequence":"first","affiliation":[{"name":"Eulerweg 4, D-64347 Griesheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2007-1019126","article-title":"Epidemiology of multiple sclerosis: From risk factors to prevention","volume":"28","author":"Ascherio","year":"2008","journal-title":"Semin. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/ana.21117","article-title":"Environmental risk factors for multiple sclerosis Part I: The role of infection","volume":"61","author":"Ascherio","year":"2007","journal-title":"Ann. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ana.20820","article-title":"Infectious mononucleosis and risk for multiple sclerosis: A meta-analysis","volume":"59","author":"Thacker","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S1474-4422(10)70094-6","article-title":"Multiple sclerosis: Risk factors prodromes and potential causal pathways","volume":"9","author":"Ramagopalan","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1177\/1352458508092353","article-title":"EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for multiple sclerosis: A case-control study","volume":"14","author":"Jidell","year":"2008","journal-title":"Mult. Scler."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S1474-4422(10)70086-7","article-title":"Vitamin D and multiple sclerosis","volume":"9","author":"Ascherio","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e16149","DOI":"10.1371\/journal.pone.0016149","article-title":"Smoking and multiple sclerosis: An updated meta-analysis","volume":"6","author":"Handel","year":"2011","journal-title":"PLoS One"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1212\/WNL.0b013e3181b59c40","article-title":"Tobacco smoking but not Swedish snuff use increases the risk of multiple sclerosis","volume":"73","author":"Olsson","year":"2009","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/01.wco.0000227033.47458.82","article-title":"Epidemiology and natural history of multiple sclerosis: New insights","volume":"19","author":"Kantarci","year":"2006","journal-title":"Curr. Opin. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000073969","article-title":"A systematic review of several potential non-genetic risk factors for multiple sclerosis","volume":"23","author":"Coo","year":"2004","journal-title":"Neuroepidemiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1474-4422(04)00933-0","article-title":"Environmental risk factors in multiple sclerosis aetiology","volume":"3","author":"Marrie","year":"2004","journal-title":"Lancet Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jneuroim.2007.11.014","article-title":"Vitamin D as an immune modulator in multiple sclerosis: A review","volume":"194","author":"Smolders","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1212\/WNL.34.11.1441","article-title":"Linoleic acid and multiple sclerosis: A reanalysis of three double-blind trials","volume":"34","author":"Dworkin","year":"1984","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/jnnp.52.1.18","article-title":"A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis","volume":"52","author":"Bates","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e002170","DOI":"10.1136\/bmjopen-2012-002170","article-title":"A novel oral nutraceutical formula of omega-3 and omega-6 fatty acids with vitamins (PLP 10) in relapsing remitting multiple sclerosis: A randomized double-blind placebo-controlled proof-of-concept clinical trial","volume":"3","author":"Pantzaris","year":"2013","journal-title":"BMJ Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1001\/archneurol.2012.283","article-title":"\u03c9-3 fatty acid treatment in multiple sclerosis (OFAMS study)","volume":"69","author":"Torkildsen","year":"2012","journal-title":"Arch. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1586\/ern.10.7","article-title":"Environmental risk factors in multiple sclerosis","volume":"10","author":"Lauer","year":"2010","journal-title":"Exp. Rev. Neurother."},{"key":"ref_18","first-page":"13","article-title":"Dietary exposures and multiple sclerosis: A review","volume":"19","author":"Lauer","year":"2011","journal-title":"Rev. Esp. Escl. M\u00falt."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/archneur.1974.00490400081010","article-title":"Multiple sclerosis and nutrition","volume":"31","author":"Alter","year":"1974","journal-title":"Arch. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0306-9877(86)90044-7","article-title":"Multiple sclerosis latitude and dietary fat: Is pork the missing link?","volume":"20","author":"Nanji","year":"1986","journal-title":"Med. Hypothes."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s10072-003-0147-6","article-title":"Risk factors of multiple sclerosis: A case-control study","volume":"24","author":"Zorzon","year":"2003","journal-title":"Neurol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ana.410050104","article-title":"Multiple sclerosis in the Faroe Islands I Clinical and epidemiologcal features","volume":"5","author":"Kurtzke","year":"1979","journal-title":"Ann. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0404.1993.tb04211.x","article-title":"Multiple sclerosis in the Faroe Islands 5 The occurrence of the fourth epidemic as validation of transmission","volume":"88","author":"Kurtzke","year":"1993","journal-title":"Acta Neurol. Scand."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-0404.1995.tb07015.x","article-title":"Multiple sclerosis in the Faroe Islands: Transmissions across four epidemics","volume":"91","author":"Kurtzke","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0895-4356(00)00268-7","article-title":"Multiple sclerosis in the Faroe Islands: An epitome","volume":"54","author":"Kurtzke","year":"2001","journal-title":"J. Clin. Epidemiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000110183","article-title":"Dietary changes in temporal relation to multiple sclerosis in the Faroe Islands An evaluation of literary sources","volume":"8","author":"Lauer","year":"1989","journal-title":"Neuroepidemiology"},{"key":"ref_27","unstructured":"Monteith, R. (1845). Description of the Islands of Orkney and Zetland [original: 1633], Thomas G. Stevenson."},{"key":"ref_28","unstructured":"Brand, J. (1703). A New Description of Orkney and Zetland, Pightland-Firth and Caithness, J.A. Taylor."},{"key":"ref_29","unstructured":"Available online: http:\/\/www.probertencyclopaedia.com\/cgi-bin\/res.pl?keyword=Vivda&offset=0."},{"key":"ref_30","unstructured":"Taste Shetland. Available online: http:\/\/www.tasteshetland.com\/history."},{"key":"ref_31","unstructured":"Nicolson, J.R. (1978). Traditional Life in Shetland, Hale."},{"key":"ref_32","unstructured":"Patursson, H. (1907). Matreglur Fyri Hv\u00f8rt Hus. F\u00f8roysk K\u00f3kib\u00f3k (in Faroese), Prentsmi\u00f0ja \u201cDimmalaetting\u201d."},{"key":"ref_33","unstructured":"Gudjonsson, S.V. (1940). P. Carl Petersen Fonds Ernaeringsexpedition til Faer\u00f8erne 1936\u20131937, Nyt Nordisk Forlag\u2013A.Busck. (in Danish)."},{"key":"ref_34","unstructured":"Scharla, N. (1934). Opskriftsbok fra Faer\u00f8ernes Husholningsskole, B.Z. Jensen. (in Danish)."},{"key":"ref_35","unstructured":"Mitens, E., and L\u00f8rup-S\u00f8rensen, C. (1953). Faer\u00f8sk lovsamling 1687\u20131953, Landsprentsmi\u00f0ian. (in Danish)."},{"key":"ref_36","unstructured":"Joensen, J.P. (1982). Fiskaf\u00f3lk, F\u00f8roya Sparikassi. (in Faroese)."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0404.1995.tb05861.x","article-title":"Environmental associations with the risk of MS: The contribution of ecological studies","volume":"91","author":"Lauer","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1352458510386997","article-title":"Multiple sclerosis: Variation of incidence of onset over time in the Faroe Islands","volume":"17","author":"Joensen","year":"2011","journal-title":"Mult. Scler."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000110199","article-title":"Multiple sclerosis in relation to meat preservation in France and Switzerland","volume":"8","author":"Lauer","year":"1989","journal-title":"Neuroepidemiology"},{"key":"ref_40","first-page":"S17","article-title":"The Fennoscandian focus of multiple sclerosis and dietary exposures: An ecological comparison","volume":"46","author":"Lauer","year":"1996","journal-title":"L\u2019Arcispedale S.Anna di Ferrara"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03670240601093300","article-title":"Sausage preservation methods and the prevalence of multiple sclerosis: An ecological study","volume":"46","author":"Lauer","year":"2007","journal-title":"Ecol. Food Nutr."},{"key":"ref_42","first-page":"S44","article-title":"Food consumption in northern and southern States of the USA: An ecological study on the risk of multiple sclerosis in space and time","volume":"15","author":"Lauer","year":"2009","journal-title":"Mult. Scler."},{"key":"ref_43","unstructured":"Darmstaedter, E., Firnhaber, W., and Lauer, K. (2009, January 16\u201319). Food consumption in Lower Saxony, northern Germany, in relation to the multiple sclerosis mortality 1975\u20131995: An ecological study. Muenster, Germany."},{"key":"ref_44","first-page":"198","article-title":"The association of the multiple sclerosis mortality 1965\u20131994 in Canada with food retail trade and food-related occupations: An ecological study","volume":"33","author":"Lauer","year":"2009","journal-title":"Neuroepidemiology"},{"key":"ref_45","first-page":"S202","article-title":"Industrial food production in countries of the European Union and the prevalence of multiple sclerosis: An ecological analysis","volume":"257","author":"Lauer","year":"2010","journal-title":"J. Neurol."},{"key":"ref_46","first-page":"S94","article-title":"Multiple sclerosis and food consumption in Austria: An ecological study","volume":"16","author":"Lauer","year":"2010","journal-title":"Mult. Scler."},{"key":"ref_47","first-page":"49","article-title":"The impact of food in the aetiology of multiple sclerosis: An ecological study in Scotland and England","volume":"17","author":"Lauer","year":"2012","journal-title":"Proc. Ger. Nutr. Soc."},{"key":"ref_48","first-page":"236","article-title":"Multiple sclerosis mortality and dietary factors in Spain: An ecological study","volume":"39","author":"Lauer","year":"2012","journal-title":"Neuroepidemiology"},{"key":"ref_49","first-page":"254","article-title":"Multiple sclerosis vitamin D and meat smoking: A global ecological study","volume":"41","author":"Lauer","year":"2013","journal-title":"Neuroepidemiology"},{"key":"ref_50","unstructured":"Lauer, K. (2014). Epidemiologist, Griesheim, Germany, Unpublished work."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Palmer, A.J., Hitchens, P.L., Simpsen, S., O\u2019Leary, B., Colman, S., and Taylor, B.V. (2013). A novel method for calculating prevalence of multiple sclerosis in Australia. Mult. Scler.","DOI":"10.1177\/1352458513479841"},{"key":"ref_52","unstructured":"McLennan, W., and Podger, A. (1999). National Nutrition Survey. Foods Eaten, Australia 1995, Australian Bureau of Statistics."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1468-1331.2011.03596.x","article-title":"Alcohol coffee fish smoking and disease progression in multiple sclerosis","volume":"19","author":"Haentjens","year":"2012","journal-title":"Eur. J. Neurol."},{"key":"ref_54","first-page":"338","article-title":"Risk and severity of multiple sclerosis in relation to defined nutritional factors during childhood: Preliminary results of a case\u2013control study","volume":"144","author":"Lauer","year":"1993","journal-title":"Schweiz. Arch. Neurol. Psychiatr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000110322","article-title":"Nutritional factors and multiple sclerosis in Gorski Kotar Croatia","volume":"12","author":"Sepcic","year":"1993","journal-title":"Neuroepidemiology"},{"key":"ref_56","first-page":"285","article-title":"Smoked meat is the main environmental risk factor in Moscow population: Data of a new case-control study","volume":"3","author":"Smirnova","year":"1997","journal-title":"Mult. Scler."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/ije\/27.5.845","article-title":"Nutritional factors in the aetiology of multiple sclerosis: A case-control study in Montreal Canada","volume":"27","author":"Ghadirian","year":"1998","journal-title":"Int. J. Epidemiol."},{"key":"ref_58","first-page":"S189","article-title":"The intake of selected foods in multiple sclerosis: A possible interaction with late childhood infections","volume":"14","author":"Lauer","year":"2008","journal-title":"Mult. Scler."},{"key":"ref_59","first-page":"S135","article-title":"The town of \u010cabar Croatia a high risk area for multiple sclerosis Analytic epidemiology of dietary factors","volume":"34","year":"2010","journal-title":"Coll. Antropol."},{"key":"ref_60","unstructured":"T\u00f3th, L. (1983). Chemie der R\u00e4ucherung, Verlag Chemie. (in German)."},{"key":"ref_61","unstructured":"Murray, T.J. (2005). Multiple Sclerosis: The History of a Disease, Demos."},{"key":"ref_62","unstructured":"Compston, A., Confavreux, C., Lassmann, H., McDonald, I., Miller, D., Noseworthy, J., Smith, K., and Wekerle, H. (2005). McAlpine\u2019s Multiple Sclerosis, Churchill Livingstone Elsevier."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0895-4356(91)90037-A","article-title":"On the history of nitrite in human nutrition: A contribution from German cookery books","volume":"44","author":"Lauer","year":"1991","journal-title":"J. Clin. Epidemiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.mehy.2006.03.044","article-title":"Divergent risk of multiple sclerosis in two Anabaptist communities in America","volume":"67","author":"Lauer","year":"2006","journal-title":"Med. Hypotheses"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/0895-4356(95)00046-1","article-title":"Varicella zoster virus and multiple sclerosis in a Hutterite population","volume":"48","author":"Ross","year":"1995","journal-title":"J. Clin. Epidemiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1017\/S0317167100038245","article-title":"The occurrence of multiple sclerosis in the Hutterites of North America","volume":"23","author":"Hader","year":"1996","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_67","first-page":"127","article-title":"Genetic conditions among Canadian Mennonites: Evidence for a founder effect among the Old Colony (Chortitza) Mennonites","volume":"12","author":"Jaworski","year":"1989","journal-title":"Clin. Investig. Med."},{"key":"ref_68","unstructured":"Peters, V. (1965). All Things Common. Hutterian Way of Life, University of Minnesota Press."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hostetler, J.A. (1997). Hutterite Society, John Hopkins University Press.","DOI":"10.56021\/9780801856396"},{"key":"ref_70","unstructured":"Shoewalter, M.E. (1956). Mennonite Community Cookbook, Universal Book and Bible House."},{"key":"ref_71","unstructured":"Rosenfeld, P., Warkentin, D.D., and Peters, J.H. (1982). The Mennonite Treasury of Recipes, Derksen Printers."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1177\/1352458507079274","article-title":"Multiple sclerosis in Kwa Zulu Natal South Africa: An epidemiological and clinical study","volume":"13","author":"Bhigjee","year":"2007","journal-title":"Mult. Scler."},{"key":"ref_73","unstructured":"Van Wyk, M., and Barton, P. (2001). Traditional South African Cooking, Central News Agency."},{"key":"ref_74","unstructured":"Van Tonder, H. (1995). Make Your Own Biltong and Dro\u00ebwors, Struik Publisher."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/aje\/152.11.1056","article-title":"Dietary fat in relation to risk of multiple sclerosis among two large cohorts of women","volume":"152","author":"Zhang","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/bmj.2.5554.724","article-title":"Annual incidence prevalence and mortality of multiple sclerosis in white South Africa born and in white immigrants to South Africa","volume":"2","author":"Dean","year":"1967","journal-title":"Br. Med. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/bmj.3.5777.725","article-title":"On the risk of multiple sclerosis according to age at immigration to South Africa","volume":"3","author":"Dean","year":"1971","journal-title":"Br. Med. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/ane.12032","article-title":"A questionnaire for multinational case-control studies of environmental factors in multiple sclerosis (EnvIMS-Q)","volume":"195","author":"Pugliatti","year":"2012","journal-title":"Acta Neurol. Scand."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Toldr\u00e1, F. (2007). Handbook of Fermented Meat and Poultry, Blackwell Publishing.","DOI":"10.1002\/9780470376430"},{"key":"ref_80","first-page":"244","article-title":"Alternatives to the use of nitrite as an antibotulinal agent","volume":"34","author":"Sofos","year":"1980","journal-title":"Food Technol."},{"key":"ref_81","unstructured":"Walker, D. (2004; p. 34). Practical Food Smoking. A Comprehensive Guide, Neil Wilson Publishing."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jsfa.2740260306","article-title":"Phenols in smoked cured meats: Nitrosation of phenols in liquid smokes and smoked bacon","volume":"26","author":"Knowles","year":"1975","journal-title":"J. Sci. Food Agric."},{"key":"ref_83","unstructured":"Potthast, K., and Hofmann, G. (1989). Abschlussbericht \u00fcber das Forschungsvorhaben \u201cEinfluss der R\u00e4uchertechnologie auf den Gehalt an Nitro- und Nitrosophenolen in ger\u00e4ucherten Fleischerzeugnissen; pr\u00e4parative Gewinnung dieser Verbindungen zur Ermittlung ihres toxischen Potentials im mikrobiologischen und\/oder biologischen Test\u201d, Bundesanstalt f\u00fcr Fleischforschung, Institut f\u00fcr Chemie und Physik. (in German)."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1021\/jf60184a018","article-title":"Interactions of some wood smoke components with epsilon-aminogroups in proteins","volume":"20","author":"Chen","year":"1972","journal-title":"J. Agric. Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1084\/jem.116.6.913","article-title":"Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens","volume":"116","author":"Weigle","year":"1962","journal-title":"J. Exp. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1084\/jem.121.2.289","article-title":"The induction of autoimmunity in rabbits following injection of heterologous or altered homologous thyreoglobulin","volume":"121","author":"Weigle","year":"1965","journal-title":"J. Exp. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1002\/eji.1830251012","article-title":"Carrier-reactive hapten-specific cytotoxic lymphocyte clones originate from a highly preselected T cell repertoire: Implications for chemical-induced self-reactivity","volume":"25","author":"Martin","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000078765","article-title":"T lymphocyte-mediated immune responses to chemical haptens and metal ions: Implications for allergic and autoimmune diseases","volume":"134","author":"Martin","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000236703","article-title":"T cell recognition of haptens a molecular view","volume":"104","author":"Martin","year":"1994","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-3083.1991.tb02489.x","article-title":"Autoreactive antibodies in thymus and spleen of neonatal and young adult BALB\/c mice: Influence of prenatal tolerization","volume":"33","author":"Achtnich","year":"1991","journal-title":"Scand. J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0016-5085(93)90436-G","article-title":"Uptake and transport of macromolecules by the intestine: Possible role in clinical disorders (an update)","volume":"104","author":"Sanderson","year":"1993","journal-title":"Gastroenterology"},{"key":"ref_92","first-page":"214","article-title":"Immunochemical detection of central nervous tissue in retail meat products using myelin prteolipid protein (PLP) as marker","volume":"58","author":"Hammon","year":"2007","journal-title":"Arch. Lebensmittelhygiene"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1079\/BJN2001314","article-title":"Brain in human nutrition and variant Creutzfeldt\u2013Jakob disease risk (vCJD): Detection of brain in retail liver sausages using cholesterol and neuron specific enolase (NSE) as markers","volume":"86","author":"Horlacher","year":"2001","journal-title":"Br. J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4315\/0362-028X-63.2.258","article-title":"Identification of central nervous system tissue in retail meat products","volume":"63","author":"Eigenbrodt","year":"2000","journal-title":"J. Food Prot."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1021\/jf100625g","article-title":"Immunochemical detection of tissue from the central nervous system via proteolipid protein: Adaptation for food inspection and development of recombinant bivalent Fab mini-antibodies","volume":"58","author":"Weigel","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0065-2628(08)60056-7","article-title":"Chemical aspects of the smoking of meat and meat products","volume":"29","author":"Potthast","year":"1984","journal-title":"Adv. Food Res."},{"key":"ref_97","first-page":"586","article-title":"Clinical and morphological findings in 30 fatal cases of infectious mononucleosis","volume":"34","author":"Lukes","year":"1958","journal-title":"Am. J. Pathol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/eji.1830220303","article-title":"Natural mouse IgG reacts with self antigens including molecules involved in the immune response","volume":"22","author":"Berneman","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaut.2013.01.006","article-title":"Natural autoantibodies in the physiology and pathophysiology of the immune system","volume":"41","author":"Avrameas","year":"2013","journal-title":"J. Autoimmun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0923-2494(96)80259-8","article-title":"Natural antibodies: The other side of the immune system","volume":"146","author":"Avrameas","year":"1995","journal-title":"Res. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Ann. Rev. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF01267771","article-title":"Monitoring of nitropolycyclic aromatic hydrocarbons in food using gas chromatography","volume":"203","author":"Schlemitz","year":"1996","journal-title":"Zschr. Lebensm. Unters. Forsch."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/02652039609374483","article-title":"Analysis of nitro-PAHs in food matrices by on-line reduction and high performance liquid chromatography","volume":"13","author":"Schlemitz","year":"1996","journal-title":"Food Additives Contam."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1081\/GNC-120016202","article-title":"The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune\/inflammatory responses and metabolic enzymes","volume":"C20","author":"Ma","year":"2002","journal-title":"J. Environ. Carcinogen. Ecotoxicol. Rev."},{"key":"ref_105","unstructured":"Raine, C.S., McFarland, H.F., and Hohlfeld, R. (2008). Multiple Sclerosis: A Comprehensive Text, Saunders\u2013Elsevier."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Alroughani, R., Ahmed, S.F., Behbahani, R., Khan, R., Thussu, A., Alexander, K.J., Ashkanani, A., Nagarajan, V., and Al-Hasel, J. (2013). Increasing prevalence and incidence rates of multiple sclerosis in Kuwait. Mult. Scler.","DOI":"10.1177\/1352458513504328"},{"key":"ref_107","unstructured":"Murphy, D. Available online: http:\/\/www.csmonitor.com\/World\/Security-Watch\/Backchannels\/2012\/0704."},{"key":"ref_108","unstructured":"Available online: http:\/\/stephencburton.com\/2013\/06\/18\/camel-meat-hot-dogs-are-now-offered-in-dubai\/."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/00207454.2011.565893","article-title":"Prevalence of multiple sclerosis in Dubai United Arab Emirates","volume":"121","author":"Inshasi","year":"2011","journal-title":"Int. J. Neurosci."},{"key":"ref_110","first-page":"S41","article-title":"Incidence and prevalence of multiple sclerosis in the United Arab Emirates A centre\u2013based study","volume":"41","author":"Auty","year":"2003","journal-title":"Mult. Scler."},{"key":"ref_111","unstructured":"Olarte-Ulherr, O. Available online: http:\/\/www.khaleejtimes\/kt-article-display-1.asp?xfile=data\/nationgeneral\/2013\/February\/nationgeneral_February426.xml&section=.nationgeneral."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/15\/3\/3533\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:08:37Z","timestamp":1760216917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/15\/3\/3533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":111,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3]]}},"alternative-id":["ijms15033533"],"URL":"https:\/\/doi.org\/10.3390\/ijms15033533","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]}}}