{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:28:03Z","timestamp":1791149283825,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite advances in neonatal intensive care leading to an increased survival rate in preterm infants, brain lesions and subsequent neurological handicaps following preterm birth remain a critical issue. To prevent brain injury and\/or enhance repair, one of the most promising therapies investigated in preclinical models is inhaled nitric oxide (iNO).  We have assessed the effect of this therapy on brain lipid content in air- and iNO-exposed rat pups by mass spectrometry imaging using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) method. This technique was used to map the variations in lipid composition of the rat brain and, particularly, of the white matter. Triplicate analysis showed a significant increase of sulfatides (25%\u201350%) in the white matter on Day 10 of life in iNO-exposed animals from Day 0\u20137 of life. These robust, repeatable and  semi-quantitative data demonstrate a potent effect of iNO at the molecular level.<\/jats:p>","DOI":"10.3390\/ijms15045233","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T12:33:44Z","timestamp":1395750824000},"page":"5233-5245","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Inhaled Nitric Oxide on the Sulfatide Profile of Neonatal Rat Brain Studied by TOF-SIMS Imaging"],"prefix":"10.3390","volume":"15","author":[{"given":"Hanane","family":"Kadar","sequence":"first","affiliation":[{"name":"Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS,  Avenue de la Terrasse, Gif-sur-Yvette Cedex 91198, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa","family":"Pham","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM) U1141,  Universit\u00e9 Paris Diderot, PRES Sorbonne Paris-cit\u00e9, H\u00f4pital Robert Debr\u00e9, 48 Boulevard S\u00e9rurier, Paris 75019, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Touboul","sequence":"additional","affiliation":[{"name":"Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS,  Avenue de la Terrasse, Gif-sur-Yvette Cedex 91198, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-6481","authenticated-orcid":false,"given":"Alain","family":"Brunelle","sequence":"additional","affiliation":[{"name":"Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS,  Avenue de la Terrasse, Gif-sur-Yvette Cedex 91198, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Baud","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM) U1141,  Universit\u00e9 Paris Diderot, PRES Sorbonne Paris-cit\u00e9, H\u00f4pital Robert Debr\u00e9, 48 Boulevard S\u00e9rurier, Paris 75019, France"},{"name":"Robert Debr\u00e9, 48 Boulevard S\u00e9rurier, Paris 75019, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e21361","DOI":"10.1371\/journal.pone.0021361","article-title":"Special care and school difficulties in 8-year-old very preterm children: The epipage cohort study","volume":"6","author":"Larroque","year":"2010","journal-title":"PLoS One"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e51879","DOI":"10.1371\/journal.pone.0051879","article-title":"Neonatal white matter abnormalities an important predictor of neurocognitive outcome for very preterm children","volume":"7","author":"Woodward","year":"2012","journal-title":"PLoS One"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"F339","DOI":"10.1136\/adc.2008.146282","article-title":"Very preterm children show impairments across multiple neurodevelopmental domains by age 4 years","volume":"94","author":"Woodward","year":"2009","journal-title":"Arch. 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