{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:09:05Z","timestamp":1773925745875,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>S-nitrosylation (SNO) is one of the most universal reversible post-translational modifications involved in many biological processes. Malfunction or dysregulation of SNO leads to a series of severe diseases, such as developmental abnormalities and various diseases. Therefore, the identification of SNO sites (SNOs) provides insights into disease progression and drug development. In this paper, a new bioinformatics tool, named PSNO, is proposed to identify SNOs from protein sequences. Firstly, we explore various promising sequence-derived discriminative features, including the evolutionary profile, the predicted secondary structure and the physicochemical properties. Secondly, rather than simply combining the features, which may bring about information redundancy and unwanted noise, we use the relative entropy selection and incremental feature selection approach  to select the optimal feature subsets. Thirdly, we train our model by the technique  of the k-nearest neighbor algorithm. Using both informative features and an elaborate  feature selection scheme, our method, PSNO, achieves good prediction performance  with a mean Mathews correlation coefficient (MCC) value of about 0.5119 on the training dataset using 10-fold cross-validation. These results indicate that PSNO can be used  as a competitive predictor among the state-of-the-art SNOs prediction tools. A web-server, named PSNO, which implements the proposed method, is freely available at http:\/\/59.73.198.144:8088\/PSNO\/.<\/jats:p>","DOI":"10.3390\/ijms150711204","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T02:28:30Z","timestamp":1403749710000},"page":"11204-11219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["PSNO: Predicting Cysteine S-Nitrosylation Sites by  Incorporating Various Sequence-Derived Features  into the General Form of Chou\u2019s PseAAC"],"prefix":"10.3390","volume":"15","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Computer Science and Information Technology, Northeast Normal University, Changchun 130017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Computer Science and Information Technology, Northeast Normal University, Changchun 130017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Computer Science and Information Technology, Northeast Normal University, Changchun 130017, China"},{"name":"National Engineering Laboratory for Druggable Gene and Protein Screening,  Northeast Normal University, Changchun 130024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Computer Science and Information Technology, Northeast Normal University, Changchun 130017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.molmed.2009.06.007","article-title":"Protein S-nitrosylation in health and disease: A current perspective","volume":"15","author":"Foster","year":"2009","journal-title":"Trends Mol. 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