{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:17:23Z","timestamp":1789406243706,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202009"],"award-info":[{"award-number":["81202009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fatty acid synthase (FASN), responsible for the de novo synthesis of  fatty acids, has been shown to act as an oncogene in various human  cancers. However, the mechanisms by which FASN favors the progression of  ovarian carcinoma remain unknown. In this study, we evaluated FASN  expression in ovarian cancer and investigated how FASN regulates the  aggressiveness of ovarian cancer cells. Our results show that increased  FASN is associated with the peritoneal metastasis of ovarian cancers.  Over-expression of FASN results in a significant increase of tumor  burden in peritoneal dissemination, accompanied by augment in cellular  colony formation and metastatic ability. Correspondingly, FASN knockdown  using RNA interference in ovarian cancer cells inhibits the migration  in vitro and experimental peritoneal dissemination in vivo. Mechanistic  studies reveal that FASN promotes Epithelial-mesenchymal Transition  (EMT) via a transcriptional regulation of  E-cadherin and N-cadherin,  which is also confirmed by luciferase promoter activity analysis. Taken  together, our work demonstrates that FASN promotes the peritoneal  dissemination of ovarian cancer cells, at least in part through the  induction of EMT.  These findings suggest that FASN plays a critical  role in the peritoneal metastasis of ovarian cancer. Targeting de novo  lipogenesis may have a therapeutic potential for advanced ovarian  cancer.<\/jats:p>","DOI":"10.3390\/ijms150711539","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T11:23:16Z","timestamp":1403868196000},"page":"11539-11554","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Up-Regulated FASN Expression Promotes Transcoelomic Metastasis of Ovarian Cancer Cell through  Epithelial-Mesenchymal Transition"],"prefix":"10.3390","volume":"15","author":[{"given":"Li","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong  University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong  University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong  University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong  University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong  University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangliang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong  University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J. 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