{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:55:20Z","timestamp":1792223720305,"version":"4.4.0"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The gaseous plant hormone ethylene regulates many aspects of plant growth, development and responses to the environment. Constitutive triple response 1 (CTR1) is  a central regulator involved in the ethylene signal transduction pathway. To obtain a better understanding of this particular pathway in cucumber, the cDNA-encoding CTR1 (designated CsCTR1) was isolated from cucumber. A sequence alignment and phylogenetic analyses revealed that CsCTR1 has a high degree of homology with other plant CTR1 proteins.  The ectopic expression of CsCTR1 in the Arabidopsis ctr1-1 mutant attenuates constitutive ethylene signaling of this mutant, suggesting that CsCTR1 indeed performs its function  as negative regulator of the ethylene signaling pathway. CsCTR1 is constitutively expressed in all of the examined cucumber organs, including roots, stems, leaves, shoot apices, mature male and female flowers, as well as young fruits. CsCTR1 expression gradually declined during male flower development and increased during female flower development. Additionally, our results indicate that CsCTR1 can be induced in the roots, leaves and shoot apices by external ethylene. In conclusion, this study provides a basis for further studies  on the role of CTR1 in the biological processes of cucumber and on the molecular mechanism of the cucumber ethylene signaling pathway.<\/jats:p>","DOI":"10.3390\/ijms150916331","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T10:31:10Z","timestamp":1410777070000},"page":"16331-16350","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ectopic Expression of CsCTR1, a Cucumber CTR-Like Gene, Attenuates Constitutive Ethylene Signaling in  an Arabidopsis ctr1-1 Mutant and Expression Pattern Analysis  of CsCTR1 in Cucumber (Cucumis sativus)"],"prefix":"10.3390","volume":"15","author":[{"given":"Beibei","family":"Bie","sequence":"first","affiliation":[{"name":"Plant Science Department, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Sun","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy,  Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsong","family":"Pan","sequence":"additional","affiliation":[{"name":"Plant Science Department, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanle","family":"He","sequence":"additional","affiliation":[{"name":"Plant Science Department, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Cai","sequence":"additional","affiliation":[{"name":"Plant Science Department, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1093\/jxb\/erp204","article-title":"Recent advances in ethylene research","volume":"60","author":"Lin","year":"2009","journal-title":"J. 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