{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:50:16Z","timestamp":1791132616110,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"publisher","award":["NSC 101-2314-B-182A-021-MY3"],"award-info":[{"award-number":["NSC 101-2314-B-182A-021-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8C0041"],"award-info":[{"award-number":["CMRPG8C0041"]}]},{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8D0201"],"award-info":[{"award-number":["CMRPG8D0201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Melatonin is an endogenously produced indoleamine and secreted by the pineal gland. Melatonin has pleiotropic bioactivities and is involved in epigenetic regulation. Suboptimal conditions during maternal and perinatal phases can elicit epigenetic regulation of genes for nephrogenesis and reset physiological responses to develop programmed hypertension. This review discusses the early utility of melatonin to prevent programmed hypertension in later life by epigenetic regulation in the kidney, with an emphasis on: (1) the role of melatonin in epigenetic regulation; (2) the beneficial effects of melatonin on programmed hypertension; (3) epigenetic regulation of maternal melatonin therapy in different developmental windows of offspring kidneys analyzed by whole-genome RNA next-generation sequencing; and (4) current blocks in the application of melatonin in preventing programmed hypertension.<\/jats:p>","DOI":"10.3390\/ijms151018484","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T10:28:18Z","timestamp":1413282498000},"page":"18484-18495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Transcriptional Regulation of Programmed Hypertension by Melatonin: An Epigenetic Perspective"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-6407","authenticated-orcid":false,"given":"You-Lin","family":"Tain","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"},{"name":"Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-288X","authenticated-orcid":false,"given":"Li-Tung","family":"Huang","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"},{"name":"Department of Traditional Chinese Medicine, Chang Gung University, Linkow 244, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Chan","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(13)60311-6","article-title":"Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease","volume":"382","author":"Luyckx","year":"2013","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrneph.2011.1","article-title":"Prenatal programming-effects on blood pressure and renal function","volume":"7","author":"Ritz","year":"2011","journal-title":"Nat. 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