{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:55:23Z","timestamp":1767909323707,"version":"3.49.0"},"reference-count":74,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic abnormalities of obesity. This review focuses on the most recently identified adipokines, namely adipocyte-fatty acid-binding protein, chemerin, fibroblast growth factor-21, lipocalin-2, omentin-1 and vaspin; their role in the pathogenesis of obesity and associated cardio-metabolic abnormalities; and on their adaptive response  to body weight change. Evidence consistently suggests a pathogenic role for A-FABP, chemerin and FGF-21. Nevertheless, large population studies are needed to verify whether they can be useful to predict the risk of cardio-metabolic abnormalities in adulthood and\/or monitor the clinical response to therapeutic interventions.<\/jats:p>","DOI":"10.3390\/ijms151119760","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T11:19:24Z","timestamp":1414581564000},"page":"19760-19776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity"],"prefix":"10.3390","volume":"15","author":[{"given":"Gloria","family":"Barraco","sequence":"first","affiliation":[{"name":"Research Unit for Multi-Factorial Diseases, Obesity and Diabetes, Scientific Directorate,  Bambino Ges\u00f9 Children Hospital, Rome 00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Luciano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Bambino Ges\u00f9 Children Hospital, Rome 00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Semeraro","sequence":"additional","affiliation":[{"name":"Research Unit for Multi-Factorial Diseases, Obesity and Diabetes, Scientific Directorate,  Bambino Ges\u00f9 Children Hospital, Rome 00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Prieto-Hontoria","sequence":"additional","affiliation":[{"name":"Faculty of Health and Physical Activity Science, University (SEK), Santiago de Chile, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-975X","authenticated-orcid":false,"given":"Melania","family":"Manco","sequence":"additional","affiliation":[{"name":"Research Unit for Multi-Factorial Diseases, Obesity and Diabetes, Scientific Directorate,  Bambino Ges\u00f9 Children Hospital, Rome 00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1210\/jc.2008-1363","article-title":"Obesity in children and adolescents","volume":"93","author":"Cali","year":"2008","journal-title":"J. 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