{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:13:25Z","timestamp":1791224005110,"version":"4.1.0"},"reference-count":171,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"US Department of Energy","award":["DE-FC02-04ER15533"],"award-info":[{"award-number":["DE-FC02-04ER15533"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atmospheric Pressure Plasma (APP) is being used widely in a variety of biomedical applications. Extensive research in the field of plasma medicine has shown the induction of DNA damage by APP in a dose-dependent manner in both prokaryotic and eukaryotic systems. Recent evidence suggests that APP-induced DNA damage shows potential benefits in many applications, such as sterilization and cancer therapy. However, in several other applications, such as wound healing and dentistry, DNA damage can be detrimental. This review reports on the extensive investigations devoted to APP interactions with DNA, with an emphasis on the critical role of reactive species in plasma-induced damage to DNA. The review consists of three main sections dedicated to fundamental knowledge of the interactions of reactive oxygen species (ROS)\/reactive nitrogen species (RNS) with DNA and its components, as well as the effects of APP on isolated and cellular DNA in prokaryotes and eukaryotes.<\/jats:p>","DOI":"10.3390\/ijms16022971","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T10:10:02Z","timestamp":1422526202000},"page":"2971-3016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":187,"title":["Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA\u2014A Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Krishna","family":"Arjunan","sequence":"first","affiliation":[{"name":"Radiation Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, School of Public Health,  Texas A&M University, 1266 TAMU, College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Ptasinska","sequence":"additional","affiliation":[{"name":"Radiation Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.physrep.2013.05.005","article-title":"Plasmas for medicine","volume":"530","author":"Reuter","year":"2013","journal-title":"Phys. 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