{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:35:02Z","timestamp":1791300902836,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aims: The aim of the present study is to investigate the differential expression of CD44, CD47 and c-met in ovarian clear cell carcinoma (OCCC), the correlation in their expression and their relationship with the biological behavior of OCCC. Methods: We used immunohistochemistry to examine the expression of CD44, CD47 and c-met in OCCC  (86 cases) and investigated the effects of the expression and interaction of these molecules on the development of OCCC. Results: CD44, CD47 and c-met expression was significantly high in OCCC. Expression of CD44 and CD47 correlated with patient surgical stage, chemotherapy resistance and prognosis (all p &lt; 0.05), and expression of c-met correlated with chemotherapy resistance and prognosis (all p &lt; 0.05), but did not correlate with lymph node metastasis (all p &gt; 0.05). The surgical stage, CD44, CD47 and c-met expression were independent risk factors for OCCC prognosis (all p &lt; 0.05). Patients with low levels of CD44, CD47 and c-met showed better survival than those with high levels (all p &lt; 0.05). There was a positive correlation between CD44 (or CD47) and c-met, as well as between CD44 and CD47 (the Spearman correlation coefficient rs was 0.783, 0.776 and 0.835, respectively, all p &lt; 0.01). Additionally, pairwise correlation analysis of these three markers shows that the high expression of CD44\/CD47, CD44\/c-met and CD47\/c-met were correlated with patient surgical stage, chemotherapy resistance and prognosis (all p &lt; 0.05), but did not correlate with lymph node metastasis (all p &gt; 0.05). Conclusions: Expression of CD44, CD47 and c-met was upregulated in OCCC and pairwise correlation. CD44, CD47 and c-met may have synergistic effects on the development of OCCC and are prognostic factors for ovarian cancer.<\/jats:p>","DOI":"10.3390\/ijms16023391","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T08:25:00Z","timestamp":1423038300000},"page":"3391-3404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Expression and Significance of CD44, CD47 and c-met in Ovarian Clear Cell Carcinoma"],"prefix":"10.3390","volume":"16","author":[{"given":"Huimin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzi","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University,  No. 36 Sanhao Street, Heping District, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ygyno.2004.04.004","article-title":"Pure-type clear cell carcinoma of the obary as a distinct histological type and improved survival in patients treated with paclitaxel-platinum-based chemotherapy in pure-type advanced disease","volume":"94","author":"Ho","year":"2004","journal-title":"Gynecol. 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