{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:23:40Z","timestamp":1764689020846,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A temperature-sensitive matrine-imprinted polymer was prepared in chloroform by free-radical cross-linking copolymerization of methacrylic acid at 60 \u00b0C in the  presence of ethylene glycol dimethacrylate as the cross-linker, N-isopropyl acrylamide  as the temperature-responsive monomer and matrine as the template molecule. Binding experiments and Scatchard analyses revealed that two classes of binding sites were formed on molecular imprinted polymer (MIP) at 50 \u00b0C. Additionally, the thermoresponsive  MIP was tested for its application as a sorbent material for the selective separation of matrine from Chinese medicinal plant radix Sophorae tonkinensis. It was shown that the thermoresponsive MIP displayed different efficiency in clean-up and enrichments using the SPE protocol at different temperatures.<\/jats:p>","DOI":"10.3390\/ijms16023441","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T08:25:00Z","timestamp":1423038300000},"page":"3441-3451","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis of a Temperature-Sensitive Matrine-Imprinted Polymer and Its Potential Application for the Selective Extraction of Matrine from Radix Sophorae Tonkinensis"],"prefix":"10.3390","volume":"16","author":[{"given":"Minjie","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road,  Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road,  Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road,  Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road,  Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road,  Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhen","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical, Guangxi Medical University, 22 Shuangyong Road,  Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weizhe","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical, Guangxi Medical University, 22 Shuangyong Road,  Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jchromb.2007.07.019","article-title":"Monodispersed, molecularly imprinted polymers as affinity-based chromatography media","volume":"866","author":"Haginaka","year":"2008","journal-title":"J. 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Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1021\/ma990719v","article-title":"Shrinking kinetics of poly (N-isopropylacrylamide) gels T-jumped across their volume phase transition temperatures","volume":"32","author":"Shibayama","year":"1999","journal-title":"Macromolecules"},{"key":"ref_8","first-page":"501","article-title":"Effects of matrine on myocardial contraction and arrhythmia in isolated heart atria","volume":"8","author":"Xin","year":"1987","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_9","first-page":"351","article-title":"Effect of matrine on lipopolysaccharides\/d-galactosamine-induced hepatitis and tumor necrosis factor release from macrophages in vitro","volume":"17","author":"Hu","year":"1996","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00216-002-1675-2","article-title":"Preparative separation and determination of matrine from the Chinese medicinal plant Sophora flavescens Ait by molecularly imprinted solid-phase extraction","volume":"375","author":"Lai","year":"2003","journal-title":"Anal. Bioanal. 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