{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:12:10Z","timestamp":1791331930280,"version":"4.3.1"},"reference-count":52,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The grants from New Century Excellent Talents in University","award":["NCET-11-0518"],"award-info":[{"award-number":["NCET-11-0518"]}]},{"name":"Doctoral Fund of Ministry of Education of China","award":["No.20120162110054"],"award-info":[{"award-number":["No.20120162110054"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Nos. 81270576, 81470362, 31101686"],"award-info":[{"award-number":["Nos. 81270576, 81470362, 31101686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Autophagy is a process that leads to the degradation of unnecessary or dysfunctional cellular components and long-lived protein aggregates. Erythropoiesis is  a branch of hematopoietic differentiation by which mature red blood cells (RBCs) are generated from multi-potential hematopoietic stem cells (HSCs). Autophagy plays a critical role in the elimination of mitochondria, ribosomes and other organelles during erythroid terminal differentiation. Here, the modulators of autophagy that regulate erythroid differentiation were summarized, including autophagy-related (Atg) genes, the  B-cell lymphoma 2 (Bcl-2) family member Bcl-2\/adenovirus E1B 19 kDa interacting protein 3-like (Nix\/Binp3L), transcription factors globin transcription factor 1 (GATA1) and forkhead box O3 (FoxO3), intermediary factor KRAB-associated protein1 (KAP1), and other modulators, such as focal adhesion kinase family-interacting protein of 200-kDa (FIP200), Ca2+ and 15-lipoxygenase. Understanding the modulators of autophagy in erythropoiesis will benefit the autophagy research field and facilitate the prevention and treatment of autophagy-related red blood cell disorders.<\/jats:p>","DOI":"10.3390\/ijms16024083","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T10:40:07Z","timestamp":1423824007000},"page":"4083-4094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Autophagy as a Regulatory Component of Erythropoiesis"],"prefix":"10.3390","volume":"16","author":[{"given":"Jieying","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China"},{"name":"Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunlu","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiling","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qikang","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"An","sequence":"additional","affiliation":[{"name":"Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA"},{"name":"College of Life Science, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1073\/pnas.68.7.1542","article-title":"Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro","volume":"68","author":"Stephenson","year":"1971","journal-title":"Proc. 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