{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:45:26Z","timestamp":1778701526717,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T00:00:00Z","timestamp":1428019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Scutellarin (1) has been used for the treatment of angina pectoris, cerebral infarction and coronary heart disease with a large market share in China. Pharmacokinetic studies on scutellarin showed that scutellarin (1) is readily converted into its metabolites in vivo. In this paper, a new and practical synthetic method for the synthesis of  6-O-methyl-scutellarein (3) (one metabolite of scutellarin in vivo) is reported. The benzyl bromide was firstly used to selectively replace the acetyl group at C-7 in 7, and was then used to protect the hydroxy groups at C-4' in 10, 6-O-methyl-scutellarein (3) is obtained in high yield through these methods.<\/jats:p>","DOI":"10.3390\/ijms16047587","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T03:47:46Z","timestamp":1428378466000},"page":"7587-7594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A New and Practical Synthetic Method for the Synthesis of  6-O-Methyl-scutellarein: One Metabolite of Scutellarin in Vivo"],"prefix":"10.3390","volume":"16","author":[{"given":"Hang","family":"Lin","sequence":"first","affiliation":[{"name":"National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, 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210023, Jiangsu, China"},{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,  Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Min","family":"Li","sequence":"additional","affiliation":[{"name":"National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 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