{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:54:28Z","timestamp":1792652068193,"version":"4.5.0"},"reference-count":79,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Interleukin-7 (IL-7) is a non-hematopoietic cell-derived cytokine with a central role in the adaptive immune system. It promotes lymphocyte development in the thymus  and maintains survival of naive and memory T cell homeostasis in the periphery. Moreover,  it is important for the organogenesis of lymph nodes (LN) and for the maintenance of activated T cells recruited into the secondary lymphoid organs (SLOs). The immune capacity of cancer patients is suppressed that is characterized by lower T cell counts, less effector immune cells infiltration, higher levels of exhausted effector cells and higher levels of immunosuppressive cytokines, such as transforming growth factor \u03b2 (TGF-\u03b2). Recombinant human IL-7 (rhIL-7) is an ideal solution for the immune reconstitution of lymphopenia patients by promoting peripheral T cell expansion. Furthermore, it can antagonize the immunosuppressive network. In animal models, IL-7 has been proven to prolong the survival of tumor-bearing hosts. In this review, we will focus on the mechanism of  action and applications of IL-7 in cancer immunotherapy and the potential restrictions for its usage.<\/jats:p>","DOI":"10.3390\/ijms160510267","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T10:58:41Z","timestamp":1430909921000},"page":"10267-10280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Mechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer Immunotherapy"],"prefix":"10.3390","volume":"16","author":[{"given":"Jianbao","family":"Gao","sequence":"first","affiliation":[{"name":"Institute of Cancer, Xinqiao Hospital, Third Military Medical University,  Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Cancer, Xinqiao Hospital, Third Military Medical University,  Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisong","family":"Wan","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill,  Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Cancer, Xinqiao Hospital, Third Military Medical University,  Chongqing 400037, China"},{"name":"Biomedical Analysis Center, Third Military Medical University, Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/3877","article-title":"Defective IL7R expression in T\u2212B+NK+ severe combined immunodeficiency","volume":"20","author":"Puel","year":"1998","journal-title":"Nat. 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