{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:36:24Z","timestamp":1791362184003,"version":"4.3.1"},"reference-count":79,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The mevalonate pathway, crucial for cholesterol synthesis, plays a key role in multiple cellular processes. Deregulation of this pathway is also correlated with diminished protein prenylation, an important post-translational modification necessary to localize certain proteins, such as small GTPases, to membranes. Mevalonate pathway blockade has been linked to mitochondrial dysfunction: especially involving lower mitochondrial membrane potential and increased release of pro-apoptotic factors in cytosol. Furthermore a severe reduction of protein prenylation has also been associated with defective autophagy, possibly causing inflammasome activation and subsequent cell death. So, it is tempting to hypothesize a mechanism in which defective autophagy fails to remove damaged mitochondria, resulting in increased cell death. This mechanism could play a significant role in Mevalonate Kinase Deficiency, an autoinflammatory disease characterized by a defect in Mevalonate Kinase, a key enzyme of the mevalonate pathway. Patients carrying mutations in the MVK gene, encoding this enzyme, show increased inflammation and lower protein prenylation levels. This review aims at analysing the correlation between mevalonate pathway defects, mitochondrial dysfunction and defective autophagy, as well as inflammation, using Mevalonate Kinase Deficiency as a model to clarify the current pathogenetic hypothesis as the basis of the disease.   <\/jats:p>","DOI":"10.3390\/ijms160716067","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T10:33:16Z","timestamp":1436956396000},"page":"16067-16084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link"],"prefix":"10.3390","volume":"16","author":[{"given":"Paola","family":"Tricarico","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazzale Europa 1, 34128 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazzale Europa 1, 34128 Trieste, Italy"},{"name":"Institute for Maternal and Child Health \"Burlo Garofolo\", via dell'Istria 65\/1, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Celsi","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health \"Burlo Garofolo\", via dell'Istria 65\/1, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1042\/bst0301091","article-title":"Sterol regulatory element-binding proteins: Transcriptional activators of lipid synthesis","volume":"30","author":"Horton","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.3748\/wjg.v10.i21.3081","article-title":"Maintaining cholesterol homeostasis: Sterol regulatory element-binding proteins","volume":"10","author":"Weber","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.plipres.2011.07.002","article-title":"Regulation of HMG-CoA reductase in mammals and yeast","volume":"50","author":"Burg","year":"2011","journal-title":"Progress Lipid Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bbrc.2007.01.155","article-title":"Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism","volume":"355","author":"Murphy","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/S0022-2275(20)34935-X","article-title":"Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways","volume":"38","author":"Hinson","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbrc.2012.10.130","article-title":"Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase","volume":"430","author":"Boonsri","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0022-2275(20)32146-5","article-title":"Characterization of phosphomevalonate kinase: Chromosomal localization, regulation, and subcellular targeting","volume":"40","author":"Olivier","year":"1999","journal-title":"J. Lipid Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1059344","article-title":"Structural mechanism for statin inhibition of HMG-CoA reductase","volume":"292","author":"Istvan","year":"2001","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/1043-6618(95)80042-5","article-title":"Pharmacology of competitive inhibitors of HMG-CoA reductase","volume":"31","author":"Corsini","year":"1995","journal-title":"Pharmacol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.7164\/antibiotics.29.1346","article-title":"ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium","volume":"29","author":"Endo","year":"1976","journal-title":"J. Antibiot. (Tokyo)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1358\/mf.2006.28.9.1003573","article-title":"Pleiotropic effects of statins and related pharmacological experimental approaches","volume":"28","author":"Alegret","year":"2006","journal-title":"Methods Find Exp. Clin. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.mehy.2007.08.030","article-title":"The lack of non-steroid isoprenoids causes oxidative stress in patients with mevalonic aciduria","volume":"70","author":"Celec","year":"2008","journal-title":"Med. Hypotheses"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrc1612","article-title":"Post-prenylation-processing enzymes as new targets in oncogenesis","volume":"5","author":"Casey","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.leu.2402476","article-title":"HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis","volume":"16","author":"Wong","year":"2002","journal-title":"Leukemia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2007.11.036","article-title":"Statins in tumor suppression","volume":"260","author":"Sassano","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2012.04.011","article-title":"Statins and cancer: Current and future prospects","volume":"324","author":"Osmak","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.atherosclerosis.2008.08.022","article-title":"The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis","volume":"203","author":"Blum","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1067\/mhj.2002.128049","article-title":"Effects of rosuvastatin and atorvastatin compared over 52 weeks of treatment in patients with hypercholesterolemia","volume":"144","author":"Olsson","year":"2002","journal-title":"Am. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1158\/1055-9965.EPI-15-0052","article-title":"Statin use and survival from lung cancer: A population-based cohort study","volume":"24","author":"Cardwell","year":"2015","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_21","first-page":"360","article-title":"Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial","volume":"23","author":"Shepherd","year":"2002","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5152\/akd.2013.4708","article-title":"The anti-inflammatory and antioxidant effects of pravastatin and nebivolol in rat aorta","volume":"14","author":"Dursun","year":"2014","journal-title":"Anadolu Kardiyol. Derg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4049\/jimmunol.170.3.1524","article-title":"A novel anti-inflammatory role for simvastatin in inflammatory arthritis","volume":"170","author":"Leung","year":"2003","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ejphar.2005.05.005","article-title":"Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis","volume":"516","author":"Barsante","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1074\/jbc.M113.536920","article-title":"Defects in mitochondrial clearance predispose human monocytes to interleukin-1\u03b2 hypersecretion","volume":"289","author":"Nijhuis","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1182\/blood-2008-03-144667","article-title":"HMG-CoA reductase inhibition induces IL-1\u03b2 release through Rac1\/PI3K\/PKB-dependent caspase-1 activation","volume":"112","author":"Kuijk","year":"2008","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1038\/cddis.2013.112","article-title":"Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line","volume":"4","author":"Marcuzzi","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijdevneu.2012.06.002","article-title":"Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line","volume":"30","author":"Marcuzzi","year":"2012","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.3390\/ijms15046843","article-title":"Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds","volume":"15","author":"Tricarico","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"27757","DOI":"10.1074\/jbc.M114.571810","article-title":"Unprenylated RhoA contributes to IL-1\u03b2 hypersecretion in mevalonate kinase deficiency model through stimulation of Rac1 activity","volume":"289","author":"Pervolaraki","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"23274","DOI":"10.3390\/ijms141223274","article-title":"Mevalonate kinase deficiency and neuroinflammation: Balance between apoptosis and pyroptosis","volume":"14","author":"Tricarico","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ygyno.2014.05.015","article-title":"Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer","volume":"134","author":"Schointuch","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_33","first-page":"610","article-title":"Simvastatin inhibits the proliferation of A549 lung cancer cells through oxidative stress and up-regulation of SOD2","volume":"69","author":"Li","year":"2014","journal-title":"Pharmazie"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.taap.2007.05.013","article-title":"Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity?","volume":"223","author":"Tavintharan","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3233\/JAD-2004-6204","article-title":"Ageing and oxidative stress: A role for dolichol in the antioxidant machinery of cell membranes?","volume":"6","author":"Bergamini","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"24832","DOI":"10.1016\/S0021-9258(19)74540-2","article-title":"Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo","volume":"268","author":"Ciosek","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.coph.2007.12.010","article-title":"New insights into mechanisms of statin-associated myotoxicity","volume":"8","author":"Sirvent","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/sj.leu.2402196","article-title":"Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells","volume":"15","author":"Xia","year":"2001","journal-title":"Leukemia (Baltimore)"},{"key":"ref_39","first-page":"2223","article-title":"Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells","volume":"5","author":"Agarwal","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1073\/pnas.1218778110","article-title":"The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway","volume":"110","author":"Rauthan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature13204","article-title":"Caenorhabditis elegans pathways that surveil and defend mitochondria","volume":"508","author":"Liu","year":"2014","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/cdd.2009.39","article-title":"Vesicular trafficking and autophagosome formation","volume":"16","author":"Longatti","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e568","DOI":"10.1038\/cddis.2013.103","article-title":"Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPases","volume":"4","author":"Zhu","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/physrev.00059.2009","article-title":"Role of Rab GTPases in membrane traffic and cell physiology","volume":"91","author":"Hutagalung","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/CIRCULATIONAHA.111.078212","article-title":"Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome","volume":"125","author":"Sciarretta","year":"2012","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1242\/jcs.031773","article-title":"Mammalian macroautophagy at a glance","volume":"122","author":"Ravikumar","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.transproceed.2008.10.009","article-title":"mTOR-what does it do?","volume":"40","author":"Hall","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.2337\/db13-0970","article-title":"Pancreatic \u03b2-cell failure mediated by mTORC1 hyperactivity and autophagic impairment","volume":"63","author":"Asahara","year":"2014","journal-title":"Diabetes"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cell.2010.12.018","article-title":"RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly","volume":"144","author":"Bodemann","year":"2011","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/jcs.123075","article-title":"The role of membrane-trafficking small GTPases in the regulation of autophagy","volume":"126","author":"Bento","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/bjc.2014.431","article-title":"In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells","volume":"111","author":"Jiang","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejphar.2011.10.044","article-title":"Hydrophobic statins induce autophagy and cell death in human rhabdomyosarcoma cells by depleting geranylgeranyl diphosphate","volume":"674","author":"Araki","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1159\/000350111","article-title":"Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes","volume":"31","author":"Wei","year":"2013","journal-title":"Cell Physiol. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-013-1358-4","article-title":"The Human Gene Mutation Database: Building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine","volume":"133","author":"Stenson","year":"2014","journal-title":"Hum. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1212\/01.WNL.0000115390.33405.F7","article-title":"Mevalonate kinase deficiency: Evidence for a phenotypic continuum","volume":"62","author":"Simon","year":"2004","journal-title":"Neurology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1542\/peds.91.5.915","article-title":"Clinical and biochemical phenotype in 11 patients with mevalonic aciduria","volume":"91","author":"Hoffmann","year":"1993","journal-title":"Pediatrics"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1172-1-13","article-title":"Mevalonate kinase deficiencies: From mevalonic aciduria to hyperimmunoglobulinemia D syndrome","volume":"1","author":"Haas","year":"2006","journal-title":"Orphanet. J. Rare Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1002\/art.22194","article-title":"A role for geranylgeranylation in interleukin-1\u03b2 secretion","volume":"54","author":"Mandey","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.molimm.2007.12.008","article-title":"Statin synergizes with LPS to induce IL-1\u03b2 release by THP-1 cells through activation of caspase-1","volume":"45","author":"Kuijk","year":"2008","journal-title":"Mol. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10545-006-0408-7","article-title":"Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis","volume":"29","author":"Cailliez","year":"2006","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1136\/ard.2011.149922","article-title":"On-demand anakinra treatment is effective in mevalonate kinase deficiency","volume":"70","author":"Bodar","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/rheumatology\/kes097","article-title":"Efficacy of interleukin-1-targeting drugs in mevalonate kinase deficiency","volume":"51","author":"Galeotti","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ejhg.2010.9","article-title":"The inhibition of mevalonate pathway induces upregulation of NALP3 expression: New insight in the pathogenesis of mevalonate kinase deficiency","volume":"18","author":"Pontillo","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e1000510","DOI":"10.1371\/journal.ppat.1000510","article-title":"The inflammasomes","volume":"5","author":"Lamkanfi","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: Guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri3532","article-title":"Autophagy in infection, inflammation and immunity","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1126\/science.1136880","article-title":"Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells","volume":"315","author":"Lee","year":"2007","journal-title":"Science"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.1104904","article-title":"Endogenous MHC class II processing of a viral nuclear antigen after autophagy","volume":"307","author":"Paludan","year":"2005","journal-title":"Science"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.immuni.2010.04.011","article-title":"Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses","volume":"32","author":"Blanchet","year":"2010","journal-title":"Immunity"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature07208","article-title":"Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance","volume":"455","author":"Nedjic","year":"2008","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1074\/jbc.M110.202911","article-title":"Autophagy Controls IL-1 Secretion by Targeting Pro-IL-1 for Degradation","volume":"286","author":"Harris","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1073\/pnas.81.24.7907","article-title":"Nucleotide sequence of human monocyte interleukin 1 precursor cDNA","volume":"81","author":"Auron","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.4049\/jimmunol.136.8.2883","article-title":"Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin","volume":"136","author":"Matsushima","year":"1986","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni.2215","article-title":"Activation of autophagy by inflammatory signals limits IL-1\u03b2 production by targeting ubiquitinated inflammasomes for destruction","volume":"13","author":"Shi","year":"2012","journal-title":"Nat. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1091\/mbc.10.5.1463","article-title":"The secretory route of the leaderless protein interleukin 1\u03b2 involves exocytosis of endolysosome-related vesicles","volume":"10","author":"Andrei","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/srep01077","article-title":"Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis","volume":"3","author":"Ding","year":"2013","journal-title":"Sci. Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/16\/7\/16067\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:49:13Z","timestamp":1760215753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/16\/7\/16067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,15]]},"references-count":79,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7]]}},"alternative-id":["ijms160716067"],"URL":"https:\/\/doi.org\/10.3390\/ijms160716067","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,15]]}}}